To Investigate the Effect of Colchicine in Prevention of Adhesions Caused by Serosal Damage in Rats

Abstract EN

Introduction and Aim.

Adhesion formation is a process which starts with an inflammation caused by a number of factors and eventually results in fibrosis.

Colchicine prevents adhesion formation which is antifibrous process.

The effectivity of colchicine in the prevention of adhesions was investigated.

Materials and Methods.

A total of 36 rats were equally divided into three groups: (I) control group 1 ( n = 12 ), (II) abrasion group 2 ( n = 12 ), and (III) abrasion + colchicine group 3 ( n = 12 ).

Group 1 underwent laparotomy and was orally given physiological serum 2 cc/day for 10 days.

In Group 2, injury was created in the cecum serosa following laparotomy and they were orally given physiological serum 2 cc/day for 10 days.

In Group 3, injury was created in the cecum serosa following laparotomy and the rats were orally given colchicine 50 mcg kg/day mixed with physiological serum 2 cc/day for 10 days.

Laparotomy was performed and adhesions were examined both macroscopically and microscopically.

Both macroscopic and microscopic examinations were performed using Zühlke’s score.

Results.

A significant difference was observed among the adhesion scores of the groups both macroscopically and microscopically.

Macroscopic score was lower in group 3 than group 2.

Microscopic score was lower in group 3 than group 2.

Conclusion.

Oral administration of colchicine is effective in the prevention of adhesions.