Radiation-Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI?
Joint Authors
Dandapani, Savita V.
Zhang, Ying
Jennelle, Richard
Lin, Yvonne G.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Purpose.
The study characterizes the impact of obesity on postoperative radiation-associated toxicities in women with endometrial cancer (EC).
Material and Methods.
A retrospective study identified 96 women with EC referred to a large urban institution’s radiation oncology practice for postoperative whole pelvic radiotherapy (WPRT) and/or intracavitary vaginal brachytherapy (ICBT).
Demographic and clinicopathologic data were obtained.
Toxicities were graded according to RTOG Acute Radiation Morbidity Scoring Criteria.
Follow-up period ranged from 1 month to 11 years (median 2 years).
Data were analyzed by χ2, logistic regression, and recursive partitioning analyses.
Results.
68 EC patients who received WPRT and/or ICBT were analyzed.
Median age was 52 years (29–73).
The majority were Hispanic (71%).
Median BMI at diagnosis was 34.5 kg/m2 (20.5–56.6 kg/m2).
BMI was independently associated with radiation-related cutaneous (p=0.022) and gynecologic-related (p=0.027) toxicities.
Younger women also reported more gynecologic-related toxicities (p=0.039).
Adjuvant radiation technique was associated with increased gastrointestinal- and genitourinary-related toxicities but not gynecologic-related toxicity.
Conclusions.
Increasing BMI was associated with increased frequency of gynecologic and cutaneous radiation-associated toxicities.
Additional studies to critically evaluate the radiation treatment dosing and treatment fields in obese EC patients are warranted to identify strategies to mitigate the radiation-associated toxicities in these women.
American Psychological Association (APA)
Dandapani, Savita V.& Zhang, Ying& Jennelle, Richard& Lin, Yvonne G.. 2015. Radiation-Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI?. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1078817
Modern Language Association (MLA)
Dandapani, Savita V.…[et al.]. Radiation-Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI?. The Scientific World Journal No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1078817
American Medical Association (AMA)
Dandapani, Savita V.& Zhang, Ying& Jennelle, Richard& Lin, Yvonne G.. Radiation-Associated Toxicities in Obese Women with Endometrial Cancer: More Than Just BMI?. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1078817
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1078817