Evolutionary Analysis of Structural Protein Gene VP1 of Foot-and-Mouth Disease Virus Serotype Asia 1
Joint Authors
Zhao, Fu-rong
Ding, Yao-zhong
Zhang, Qingxun
Fang, Yuzhen
Pan, Li
Lv, Jianliang
Zhang, Zhongwang
Zhou, Peng
Zhang, Jie
Wang, Yonglu
Zhang, Yongguang
Shao, Jun-jun
Lin, Tong
Chang, Hui-yun
Liu, Xin-sheng
Chen, Hao-tai
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-02-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Foot-and-mouth disease virus (FMDV) serotype Asia 1 was mostly endemic in Asia and then was responsible for economically important viral disease of cloven-hoofed animals, but the study on its selection and evolutionary process is comparatively rare.
In this study, we characterized 377 isolates from Asia collected up until 2012, including four vaccine strains.
Maximum likelihood analysis suggested that the strains circulating in Asia were classified into 8 different groups (groups I–VIII) or were unclassified (viruses collected before 2000).
On the basis of divergence time analyses, we infer that the TMRCA of Asia 1 virus existed approximately 86.29 years ago.
The result suggested that the virus had a high mutation rate (5.745 × 10−3 substitutions/site/year) in comparison to the other serotypes of FMDV VP1 gene.
Furthermore, the structural protein VP1 was under lower selection pressure and the positive selection occurred at many sites, and four codons (positions 141, 146, 151, and 169) were located in known critical antigenic residues.
The remaining sites were not located in known functional regions and were moderately conserved, and the reason for supporting all sites under positive selection remains to be elucidated because the power of these analyses was largely unknown.
American Psychological Association (APA)
Zhang, Qingxun& Liu, Xin-sheng& Fang, Yuzhen& Pan, Li& Lv, Jianliang& Zhang, Zhongwang…[et al.]. 2015. Evolutionary Analysis of Structural Protein Gene VP1 of Foot-and-Mouth Disease Virus Serotype Asia 1. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1079069
Modern Language Association (MLA)
Zhang, Qingxun…[et al.]. Evolutionary Analysis of Structural Protein Gene VP1 of Foot-and-Mouth Disease Virus Serotype Asia 1. The Scientific World Journal No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1079069
American Medical Association (AMA)
Zhang, Qingxun& Liu, Xin-sheng& Fang, Yuzhen& Pan, Li& Lv, Jianliang& Zhang, Zhongwang…[et al.]. Evolutionary Analysis of Structural Protein Gene VP1 of Foot-and-Mouth Disease Virus Serotype Asia 1. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1079069
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1079069