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Histological and morphological study of cerebrum and cerebellum of albino rats treated with antiandrogen flutamide
Author
Source
Journal of Babylon University : Journal of Applied and Pure Sciences
Issue
Vol. 26, Issue 2 (28 Feb. 2018), pp.99-108, 10 p.
Publisher
Publication Date
2018-02-28
Country of Publication
Iraq
No. of Pages
10
Main Subjects
Abstract EN
The present study was aimed to assess the effects of antiandrogen flutamide on some histological and morphometric cerebrum and cerebellum tissue for white albino rats, Twenty five male rats were divided into five groups each group contains 5 animals, the first and second group regarded as positive and negative control, respectively, while the other groups was treated with flutamide drug orally for 28 days at concentrations of (8, 12, 25 mg/kg/day).
Histopathological results revealed that there is a significant increase in cell number of outer granular layers in cerebrum of the groups treated with 25 mg/kg/day compared to positive and negative control group as well as with other treated groups cerebrum, also the results of histopathological pointed that there were no significant differences in cerebellum tissue in all treated groups .
The morphometric results showed that there were no significant differences in thickness of cerebellar layers among different groups , therefore antiandrogen flutamide can be considered as a testosterone modulator.
To determine more precise effect of flutamide on the brain, further studies are needed.
American Psychological Association (APA)
Hammud, Hanan Jasim. 2018. Histological and morphological study of cerebrum and cerebellum of albino rats treated with antiandrogen flutamide. Journal of Babylon University : Journal of Applied and Pure Sciences،Vol. 26, no. 2, pp.99-108.
https://search.emarefa.net/detail/BIM-1094053
Modern Language Association (MLA)
Hammud, Hanan Jasim. Histological and morphological study of cerebrum and cerebellum of albino rats treated with antiandrogen flutamide. Journal of Babylon University : Journal of Applied and Pure Sciences Vol. 26, no. 2 (2018), pp.99-108.
https://search.emarefa.net/detail/BIM-1094053
American Medical Association (AMA)
Hammud, Hanan Jasim. Histological and morphological study of cerebrum and cerebellum of albino rats treated with antiandrogen flutamide. Journal of Babylon University : Journal of Applied and Pure Sciences. 2018. Vol. 26, no. 2, pp.99-108.
https://search.emarefa.net/detail/BIM-1094053
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 106-108
Record ID
BIM-1094053