Mast Cell Interaction with Neutrophils in Human Gastric Carcinomas: Ultrastructural Observations
Joint Authors
Ieni, A.
Branca, Giovanni
Alberto Caruso, Rosario
Barresi, Valeria
Tuccari, Giovanni
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-02
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aim.
The role of mast cells in cell-cell immune interactions has received increasing attention, although their functional interaction with neutrophils still remains to be clarified in tumors.
The aim of the present study was to investigate the association between mast cells and neutrophils in a series of gastric carcinomas (GC).
Patients and Methods.
52 surgically resected GC specimens were routinely processed for both light and electron microscopy.
Only cases showing both mast cells and neutrophils in the tumor stroma were considered in the analysis.
Results.
Only 9 GC (M : F = 5 : 4; age range: 50–82 years) showed both mast cells and neutrophils in the tumor stroma.
At ultrathin sections, we identified heterotypic aggregation and intermingling of mast cells and neutrophils.
Mast cells had mature phenotype and showed full complement of granules with homogeneous, scroll, particle, and mixed pattern.
In addition, we found normal-appearing or early apoptosis showing neutrophils.
Conclusion.
Our histological findings showed the likely interaction between mast cells and neutrophils in GC.
We hypothesize that the granular content of mast cells may be released in small quantity through a mechanism called “kiss-and-run fusion,” which is alternative to well-known massive anaphylactic or piecemeal degranulation.
American Psychological Association (APA)
Ieni, A.& Barresi, Valeria& Branca, Giovanni& Alberto Caruso, Rosario& Tuccari, Giovanni. 2016. Mast Cell Interaction with Neutrophils in Human Gastric Carcinomas: Ultrastructural Observations. Analytical Cellular Pathology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1094970
Modern Language Association (MLA)
Ieni, A.…[et al.]. Mast Cell Interaction with Neutrophils in Human Gastric Carcinomas: Ultrastructural Observations. Analytical Cellular Pathology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1094970
American Medical Association (AMA)
Ieni, A.& Barresi, Valeria& Branca, Giovanni& Alberto Caruso, Rosario& Tuccari, Giovanni. Mast Cell Interaction with Neutrophils in Human Gastric Carcinomas: Ultrastructural Observations. Analytical Cellular Pathology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1094970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1094970