Correlation of Serum Soluble Interleukin-7 Receptor and Anti-C1q Antibody in Patients with Systemic Lupus Erythematosus
Joint Authors
Chi, Shuhong
Yu, Yunxia
Zhang, Yurong
Yang, Jijuan
Yang, Lijuan
Xue, Jing
Li, Feng
Zhu, Caixia
Li, Haibo
Wang, Xuemei
Zhou, Shaolan
Ji, Chen
Liu, Xiaoming
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Serum concentrations of soluble interleukin-7 receptor (sIL-7R) and anti-C1q antibody have recently been identified as unique serological markers for lupus nephritis (LN) in patients with systemic lupus erythematosus (SLE).
In this study, we evaluated the correlation of serum sIL-7R and anti-C1q in SLE patients.
Methods.
Sera from 134 patients with SLE and 84 healthy cohorts were tested for levels of sIL-7R and anti-C1q antibodies in terms of ELISA.
Correlations of the sIL-7R and anti-C1q autoantibodies were evaluated.
Results.
The serum concentrations of sIL-7R and anti-C1q antibodies were significantly higher in SLE patients and LN patients in comparison with healthy individuals/controls and SLE patients with non-LN, respectively.
In addition, both sIL-7R and anti-C1q concentrations were found to significantly correlate with the SLE disease activity as evaluated by SLEDAI scores.
Interestingly, the serum sIL-7R concentration was strongly correlated with the level of anti-C1q antibodies (r=0.2871, p=0.0008) but not statistically correlated with other serological markers, including the anti-dsDNA and complements C3 and C4 concentrations in SLE patients.
Conclusion.
Both serum sIL-7R and anti-C1q antibodies were strongly associated with disease activity and LN in SLE patients, suggesting that they may be reliable serological markers for identification of SLE patients with active diseases and LN.
American Psychological Association (APA)
Chi, Shuhong& Xue, Jing& Li, Feng& Zhu, Caixia& Yu, Yunxia& Li, Haibo…[et al.]. 2016. Correlation of Serum Soluble Interleukin-7 Receptor and Anti-C1q Antibody in Patients with Systemic Lupus Erythematosus. Autoimmune Diseases،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1094988
Modern Language Association (MLA)
Chi, Shuhong…[et al.]. Correlation of Serum Soluble Interleukin-7 Receptor and Anti-C1q Antibody in Patients with Systemic Lupus Erythematosus. Autoimmune Diseases No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1094988
American Medical Association (AMA)
Chi, Shuhong& Xue, Jing& Li, Feng& Zhu, Caixia& Yu, Yunxia& Li, Haibo…[et al.]. Correlation of Serum Soluble Interleukin-7 Receptor and Anti-C1q Antibody in Patients with Systemic Lupus Erythematosus. Autoimmune Diseases. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1094988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1094988