A Review on Potential Mechanisms of Terminalia chebula in Alzheimer’s Disease
Joint Authors
Sadeghnia, Hamid Reza
Afshari, Amir R.
Mollazadeh, Hamid
Source
Advances in Pharmacological and Pharmaceutical Sciences
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The current management of Alzheimer’s disease (AD) focuses on acetylcholinesterase inhibitors (AChEIs) and NMDA receptor antagonists, although outcomes are not completely favorable.
Hence, novel agents found in herbal plants are gaining attention as possible therapeutic alternatives.
The Terminalia chebula (Family: Combretaceae) is a medicinal plant with a wide spectrum of medicinal properties and is reported to contain various biochemicals such as hydrolysable tannins, phenolic compounds, and flavonoids, so it may prove to be a good therapeutic alternative.
In this research, we reviewed published scientific literature found in various databases: PubMed, Science Direct, Scopus, Web of Science, Scirus, and Google Scholar, with the keywords: T.
chebula, AD, neuroprotection, medicinal plant, antioxidant, ellagitannin, gallotannin, gallic acid, chebulagic acid, and chebulinic acid.
This review shows that T.
chebula extracts and its constituents have AChEI and antioxidant and anti-inflammatory effects, all of which are currently relevant to the treatment of Alzheimer’s disease.
American Psychological Association (APA)
Afshari, Amir R.& Sadeghnia, Hamid Reza& Mollazadeh, Hamid. 2016. A Review on Potential Mechanisms of Terminalia chebula in Alzheimer’s Disease. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1096634
Modern Language Association (MLA)
Afshari, Amir R.…[et al.]. A Review on Potential Mechanisms of Terminalia chebula in Alzheimer’s Disease. Advances in Pharmacological and Pharmaceutical Sciences No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1096634
American Medical Association (AMA)
Afshari, Amir R.& Sadeghnia, Hamid Reza& Mollazadeh, Hamid. A Review on Potential Mechanisms of Terminalia chebula in Alzheimer’s Disease. Advances in Pharmacological and Pharmaceutical Sciences. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1096634
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096634