Granisetron versus Granisetron-Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Pediatric Strabismus Surgery: A Randomized Double-Blind Trial
Joint Authors
Sinha, Renu
Ray, Bikash Ranjan
Shende, Dilip
Kumar, Neeraj
Mohan, Virender Kumar
Maitra, Souvik
Source
Anesthesiology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
Efficacy of granisetron and combination of granisetron and dexamethasone was evaluated for prevention of postoperative nausea and vomiting (PONV) in children undergoing elective strabismus surgery.
Methods.
A total of 136 children (1–15 years) were included.
Children received either granisetron (40 mcg/kg) [group G] or combination of granisetron (40 mcg/kg) and dexamethasone (150 mcg/kg) [group GD].
Intraoperative fentanyl requirement and incidence and severity of oculocardiac reflex were assessed.
PONV severity was assessed for first 24 hours and if score was >2, it was treated with metoclopramide.
Postoperative analgesia was administered with intravenous fentanyl and ibuprofen.
Results.
The demographic profile, muscles operated, and fentanyl requirement were comparable.
Complete response to PONV in first 24 hours was observed in 75% (51/68) of children in group G and 76.9% (50/65) of children in group GD, which was comparable statistically ( p = 0.96 , Fisher exact test; OR 1.11, 95% CI 0.50, 2.46).
Incidence of PONV between 0 and 24 hours was comparable.
One child in group G required rescue antiemetic in first 24 hours and none of the children had severe PONV in group GD.
There was no significant difference in incidence or severity of oculocardiac reflex.
Conclusion.
Dexamethasone did not increase efficacy of granisetron for prevention of PONV in elective pediatric strabismus surgery.
Registration number of clinical trial was CTRI/2009/091/001000.
American Psychological Association (APA)
Sinha, Renu& Shende, Dilip& Maitra, Souvik& Kumar, Neeraj& Ray, Bikash Ranjan& Mohan, Virender Kumar. 2016. Granisetron versus Granisetron-Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Pediatric Strabismus Surgery: A Randomized Double-Blind Trial. Anesthesiology Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1096667
Modern Language Association (MLA)
Sinha, Renu…[et al.]. Granisetron versus Granisetron-Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Pediatric Strabismus Surgery: A Randomized Double-Blind Trial. Anesthesiology Research and Practice No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1096667
American Medical Association (AMA)
Sinha, Renu& Shende, Dilip& Maitra, Souvik& Kumar, Neeraj& Ray, Bikash Ranjan& Mohan, Virender Kumar. Granisetron versus Granisetron-Dexamethasone for Prevention of Postoperative Nausea and Vomiting in Pediatric Strabismus Surgery: A Randomized Double-Blind Trial. Anesthesiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1096667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096667