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Association of Aortic Compliance and Brachial Endothelial Function with Cerebral Small Vessel Disease in Type 2 Diabetes Mellitus Patients: Assessment with High-Resolution MRI
Joint Authors
Zeng, Meng-Su
Shan, Yan
Lin, Jiang
Xu, Pengju
Lin, Huandong
Yan, Hongmei
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To assess the possible association of aortic compliance and brachial endothelial function with cerebral small vessel disease in type 2 diabetes mellitus (DM2) patients by using 3.0 T high-resolution magnetic resonance imaging.
Methods.
Sixty-two clinically confirmed DM2 patients (25 women and 37 men; mean age: 56.8±7.5 years) were prospectively enrolled for noninvasive MR examinations of the aorta, brachial artery, and brain.
Aortic arch pulse wave velocity (PWV), flow-mediated dilation (FMD) of brachial artery, lacunar brain infarcts, and periventricular and deep white matter hyperintensities (WMHs) were assessed.
Pearson and Spearman correlation analysis were performed to analyze the association between PWV and FMD with clinical data and biochemical test results.
Univariable logistic regression analyses were used to analyze the association between PWV and FMD with cerebral small vessel disease.
Multiple logistic regression analyses were used to find out the independent predictive factors of cerebral small vessel disease.
Results.
Mean PWV was 6.73±2.00 m/s and FMD was 16.67±9.11%.
After adjustment for compounding factors, PWV was found significantly associated with lacunar brain infarcts (OR = 2.00; 95% CI: 1.14–3.2; P<0.05) and FMD was significantly associated with periventricular WMHs (OR = 0.82; 95% CI: 0.71–0.95; P<0.05).
Conclusions.
Quantitative evaluation of aortic compliance and endothelial function by using high-resolution MRI may be potentially useful to stratify DM2 patients with risk of cerebral small vessel disease.
American Psychological Association (APA)
Shan, Yan& Lin, Jiang& Xu, Pengju& Zeng, Meng-Su& Lin, Huandong& Yan, Hongmei. 2016. Association of Aortic Compliance and Brachial Endothelial Function with Cerebral Small Vessel Disease in Type 2 Diabetes Mellitus Patients: Assessment with High-Resolution MRI. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096919
Modern Language Association (MLA)
Shan, Yan…[et al.]. Association of Aortic Compliance and Brachial Endothelial Function with Cerebral Small Vessel Disease in Type 2 Diabetes Mellitus Patients: Assessment with High-Resolution MRI. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1096919
American Medical Association (AMA)
Shan, Yan& Lin, Jiang& Xu, Pengju& Zeng, Meng-Su& Lin, Huandong& Yan, Hongmei. Association of Aortic Compliance and Brachial Endothelial Function with Cerebral Small Vessel Disease in Type 2 Diabetes Mellitus Patients: Assessment with High-Resolution MRI. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1096919