Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis
Joint Authors
Lupia, Enrico
Mengozzi, Giulio
Battista, Stefania
Audisio, Umberto
Galluzzo, Claudia
Maggiorotto, Matteo
Masoero, Monica
Forno, Daniela
Pizzolato, Elisa
Ulla, Marco
Lucchiari, Manuela
Vitale, Annarita
Moiraghi, Corrado
Settanni, Fabio
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The diagnostic and prognostic usefulness of copeptin were evaluated in septic patients, as compared to procalcitonin assessment.
In this single centre and observational study 105 patients were enrolled: 24 with sepsis, 25 with severe sepsis, 15 with septic shock, and 41 controls, divided in two subgroups (15 patients with gastrointestinal bleeding and 26 with suspected SIRS secondary to trauma, acute coronary syndrome, and pulmonary embolism).
Biomarkers were determined at the first medical evaluation and thereafter 24, 48, and 72 hours after admission.
Definitive diagnosis and in-hospital survival rates at 30 days were obtained through analysis of medical records.
At entry, copeptin proved to be able to distinguish cases from controls and also sepsis group from septic shock group, while procalcitonin could distinguish also severe sepsis from septic shock group.
Areas under the ROC curve for copeptin and procalcitonin were 0.845 and 0.861, respectively.
Noteworthy, patients with copeptin concentrations higher than the threshold value (23.2 pmol/L), calculated from the ROC curve, at admission presented higher 30-day mortality.
No significant differences were found in copeptin temporal profile among different subgroups.
Copeptin showed promising diagnostic and prognostic role in the management of sepsis, together with its possible role in monitoring the response to treatment.
American Psychological Association (APA)
Battista, Stefania& Audisio, Umberto& Galluzzo, Claudia& Maggiorotto, Matteo& Masoero, Monica& Forno, Daniela…[et al.]. 2016. Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097385
Modern Language Association (MLA)
Battista, Stefania…[et al.]. Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1097385
American Medical Association (AMA)
Battista, Stefania& Audisio, Umberto& Galluzzo, Claudia& Maggiorotto, Matteo& Masoero, Monica& Forno, Daniela…[et al.]. Assessment of Diagnostic and Prognostic Role of Copeptin in the Clinical Setting of Sepsis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097385