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Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment
Joint Authors
Martínez-Montiel, Nancy
Rosas-Murrieta, Nora Hilda
Martínez-Montiel, Mónica
Gaspariano-Cholula, Mayra Patricia
Martínez-Contreras, Rebeca D.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
In eukaryotes, genes are frequently interrupted with noncoding sequences named introns.
Alternative splicing is a nuclear mechanism by which these introns are removed and flanking coding regions named exons are joined together to generate a message that will be translated in the cytoplasm.
This mechanism is catalyzed by a complex machinery known as the spliceosome, which is conformed by more than 300 proteins and ribonucleoproteins that activate and regulate the precision of gene expression when assembled.
It has been proposed that several genetic diseases are related to defects in the splicing process, including cancer.
For this reason, natural products that show the ability to regulate splicing have attracted enormous attention due to its potential use for cancer treatment.
Some microbial metabolites have shown the ability to inhibit gene splicing and the molecular mechanism responsible for this inhibition is being studied for future applications.
Here, we summarize the main types of natural products that have been characterized as splicing inhibitors, the recent advances regarding molecular and cellular effects related to these molecules, and the applications reported so far in cancer therapeutics.
American Psychological Association (APA)
Martínez-Montiel, Nancy& Rosas-Murrieta, Nora Hilda& Martínez-Montiel, Mónica& Gaspariano-Cholula, Mayra Patricia& Martínez-Contreras, Rebeca D.. 2016. Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment. BioMed Research International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1097402
Modern Language Association (MLA)
Martínez-Montiel, Nancy…[et al.]. Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment. BioMed Research International No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1097402
American Medical Association (AMA)
Martínez-Montiel, Nancy& Rosas-Murrieta, Nora Hilda& Martínez-Montiel, Mónica& Gaspariano-Cholula, Mayra Patricia& Martínez-Contreras, Rebeca D.. Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1097402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097402