Cementless Titanium Mesh Fixation of Osteoporotic Burst Fractures of the Lumbar Spine Leads to Bony Healing: Results of an Experimental Sheep Model
Joint Authors
Mittlmeier, Thomas
Gradl, Georg
Vollmar, Brigitte
Roepenack, Paula
Roesner, Jan
Martin, Heiner
Reichel, Martin
Rotter, Robert
Herlyn, Philipp
Eschler, Anica
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
Current treatment strategies for osteoporotic vertebral compression fractures (VCFs) focus on cement-associated solutions.
Complications associated with cement application are leakage, embolism, adjacent fractures, and compromise in bony healing.
This study comprises a validated VCF model in osteoporotic sheep in order to (1) evaluate a new cementless fracture fixation technique using titanium mesh implants (TMIs) and (2) demonstrate the healing capabilities in osteoporotic VCFs.
Methods.
Twelve 5-year-old Merino sheep received ovariectomy, corticosteroid injections, and a calcium/phosphorus/vitamin D-deficient diet for osteoporosis induction.
Standardized VCFs (type AO A3.1) were created, reduced, and fixed using intravertebral TMIs.
Randomly additional autologous spongiosa grafting (G1) or no augmentation was performed (G2, n = 6 each).
Two months postoperatively, macroscopic, micro-CT and biomechanical evaluation assessed bony consolidation.
Results.
Fracture reduction succeeded in all cases without intraoperative complications.
Bony consolidation was proven for all cases with increased amounts of callus development for G2 (58.3%).
Micro-CT revealed cage integration.
Neither group showed improved results with biomechanical testing.
Conclusions.
Fracture reduction/fixation using TMIs without cement in osteoporotic sheep lumbar VCF resulted in bony fracture healing.
Intravertebral application of autologous spongiosa showed no beneficial effects.
The technique is now available for clinical use; thus, it offers an opportunity to abandon cement-associated complications.
American Psychological Association (APA)
Eschler, Anica& Roepenack, Paula& Roesner, Jan& Herlyn, Philipp& Martin, Heiner& Reichel, Martin…[et al.]. 2016. Cementless Titanium Mesh Fixation of Osteoporotic Burst Fractures of the Lumbar Spine Leads to Bony Healing: Results of an Experimental Sheep Model. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097662
Modern Language Association (MLA)
Eschler, Anica…[et al.]. Cementless Titanium Mesh Fixation of Osteoporotic Burst Fractures of the Lumbar Spine Leads to Bony Healing: Results of an Experimental Sheep Model. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1097662
American Medical Association (AMA)
Eschler, Anica& Roepenack, Paula& Roesner, Jan& Herlyn, Philipp& Martin, Heiner& Reichel, Martin…[et al.]. Cementless Titanium Mesh Fixation of Osteoporotic Burst Fractures of the Lumbar Spine Leads to Bony Healing: Results of an Experimental Sheep Model. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097662