Effects of Lycium barbarum Polysaccharides on Apoptosis, Cellular Adhesion, and Oxidative Damage in Bone Marrow Mononuclear Cells of Mice Exposed to Ionizing Radiation Injury
Joint Authors
Zhou, Jing
Pang, Hua
Li, Wenbo
Liu, Qiong
Xu, Lu
Liu, Qian
Liu, Ying
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Lycium barbarum has been used for more than 2500 years as a traditional herb and food in China.
We investigated the effects of Lycium barbarum polysaccharides (LBP) on apoptosis, oxidative damage, and expression of adhesion molecules in bone marrow mononuclear cells (BMNC) of mice injured by ionizing radiation.
Kunming mice were exposed to X-rays; then mice in the LBP groups were continuously injected with various concentrations of LBP intraperitoneally for 14 days.
Mice in the control group were continuously injected with normal saline (NS) by the same route for 14 days.
A normal group was set up.
After 1, 7, and 14 days of treatment, mice were killed and BMNC were extracted.
Cell cycle, apoptosis, and the expression of adhesion molecules CD44 and CD49d were detected by flow cytometry.
The levels of malondialdehyde (MDA) and superoxide dismutase (SOD) were identified by colorimetric analyses.
LBP significantly decreased the percentage of G0/G1 phase, apoptosis, MDA level, and expression of CD44 and CD49d and distinctly increased the activity of SOD.
LBP showed a protective effect on BMNC against ionizing radiation-induced apoptosis and oxidative damage and altered the expression of adhesion molecule.
American Psychological Association (APA)
Zhou, Jing& Pang, Hua& Li, Wenbo& Liu, Qiong& Xu, Lu& Liu, Qian…[et al.]. 2016. Effects of Lycium barbarum Polysaccharides on Apoptosis, Cellular Adhesion, and Oxidative Damage in Bone Marrow Mononuclear Cells of Mice Exposed to Ionizing Radiation Injury. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097678
Modern Language Association (MLA)
Zhou, Jing…[et al.]. Effects of Lycium barbarum Polysaccharides on Apoptosis, Cellular Adhesion, and Oxidative Damage in Bone Marrow Mononuclear Cells of Mice Exposed to Ionizing Radiation Injury. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1097678
American Medical Association (AMA)
Zhou, Jing& Pang, Hua& Li, Wenbo& Liu, Qiong& Xu, Lu& Liu, Qian…[et al.]. Effects of Lycium barbarum Polysaccharides on Apoptosis, Cellular Adhesion, and Oxidative Damage in Bone Marrow Mononuclear Cells of Mice Exposed to Ionizing Radiation Injury. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097678
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1097678