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HMBA Enhances Prostratin-Induced Activation of Latent HIV-1 via Suppressing the Expression of Negative Feedback Regulator A20TNFAIP3 in NF-κB Signaling
Joint Authors
Chen, Ruichuan
Chen, Duchu
Aweya, Jude Juventus
Chen, Meihua
Wu, Xiaomeng
Chen, Xiaonan
Lu, Jing
Liu, Min
Chen, Yanheng
Wang, Huiping
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In the past decade, much emphasis has been put on the transcriptional activation of HIV-1, which is proposed as a promised strategy for eradicating latent HIV-1 provirus.
Two drugs, prostratin and hexamethylene bisacetamide (HMBA), have shown potent effects as inducers for releasing HIV-1 latency when used alone or in combination, although their cellular target(s) are currently not well understood, especially under drug combination.
Here, we have shown that HMBA and prostratin synergistically release HIV-1 latency via different mechanisms.
While prostratin strongly stimulates HMBA-induced HIV-1 transcription via improved P-TEFb activation, HMBA is capable of boosting NF-κB-dependent transcription initiation by suppressing prostratin-induced expression of the deubiquitinase A20, a negative feedback regulator in the NF-κB signaling pathway.
In addition, HMBA was able to increase prostratin-induced phosphorylation and degradation of NF-κB inhibitor IκBα, thereby enhancing and prolonging prostratin-induced nuclear translocation of NF-κB, a prerequisite for stimulation of transcription initiation.
Thus, by blocking the negative feedback circuit, HMBA functions as a signaling enhancer of the NF-κB signaling pathway.
American Psychological Association (APA)
Chen, Duchu& Wang, Huiping& Aweya, Jude Juventus& Chen, Yanheng& Chen, Meihua& Wu, Xiaomeng…[et al.]. 2016. HMBA Enhances Prostratin-Induced Activation of Latent HIV-1 via Suppressing the Expression of Negative Feedback Regulator A20TNFAIP3 in NF-κB Signaling. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1098017
Modern Language Association (MLA)
Chen, Duchu…[et al.]. HMBA Enhances Prostratin-Induced Activation of Latent HIV-1 via Suppressing the Expression of Negative Feedback Regulator A20TNFAIP3 in NF-κB Signaling. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1098017
American Medical Association (AMA)
Chen, Duchu& Wang, Huiping& Aweya, Jude Juventus& Chen, Yanheng& Chen, Meihua& Wu, Xiaomeng…[et al.]. HMBA Enhances Prostratin-Induced Activation of Latent HIV-1 via Suppressing the Expression of Negative Feedback Regulator A20TNFAIP3 in NF-κB Signaling. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1098017
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098017