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Effect of LongZhang Gargle on Biofilm Formation and Acidogenicity of Streptococcus mutans In Vitro
Joint Authors
Yang, Yutao
Liu, Shiyu
He, Yuanli
Chen, Zhu
Li, Mingyun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Streptococcus mutans, with the ability of high-rate acid production and strong biofilm formation, is considered the predominant bacterial species in the pathogenesis of human dental caries.
Natural products which may be bioactive against S.
mutans have become a hot spot to researches to control dental caries.
LongZhang Gargle, completely made from Chinese herbs, was investigated for its effects on acid production and biofilm formation by S.
mutans in this study.
The results showed an antimicrobial activity of LongZhang Gargle against S.
mutans planktonic growth at the minimum inhibitory concentration (MIC) of 16% and minimum bactericidal concentration (MBC) of 32%.
Acid production was significantly inhibited at sub-MIC concentrations.
Biofilm formation was also significantly disrupted, and 8% was the minimum concentration that resulted in at least 50% inhibition of biofilm formation (MBIC50).
A scanning electron microscopy (SEM) showed an effective disruption of LongZhang Gargle on S.
mutans biofilm integrity.
In addition, a confocal laser scanning microscopy (CLSM) suggested that the extracellular polysaccharides (EPS) synthesis could be inhibited by LongZhang Gargle at a relatively low concentration.
These findings suggest that LongZhang Gargle may be a promising natural anticariogenic agent in that it suppresses planktonic growth, acid production, and biofilm formation against S.
mutans.
American Psychological Association (APA)
Yang, Yutao& Liu, Shiyu& He, Yuanli& Chen, Zhu& Li, Mingyun. 2016. Effect of LongZhang Gargle on Biofilm Formation and Acidogenicity of Streptococcus mutans In Vitro. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098229
Modern Language Association (MLA)
Yang, Yutao…[et al.]. Effect of LongZhang Gargle on Biofilm Formation and Acidogenicity of Streptococcus mutans In Vitro. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098229
American Medical Association (AMA)
Yang, Yutao& Liu, Shiyu& He, Yuanli& Chen, Zhu& Li, Mingyun. Effect of LongZhang Gargle on Biofilm Formation and Acidogenicity of Streptococcus mutans In Vitro. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098229
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098229