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The Effect of Advanced Motherhood on Newborn Offspring’s Hippocampal Neural Stem Cell Proliferation
Joint Authors
Li, Bo
Duan, Ping
Han, Xuefei
Yan, Wenhai
Xing, Ying
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To investigate the effect of advanced motherhood on rat hippocampal neural stem cell proliferation.
Methods.
Female parents were subdivided into control and old mother group by age, and neural stem cells were cultured from hippocampal tissues for 24 h newborn offspring.
The diameter and numbers of neurospheres were examined by microscopy, and differences in proliferation were examined by EdU immunofluorescence, CCK-8 assay, and cell cycle analysis.
Results.
The number of neurospheres in the old mother group after culture was lower than the control group.
Additionally, neurospheres’ diameter was smaller than that of the control group (P<0.05).
The EdU positive rate of the old mother group was lower than that of the control group (P<0.05).
CCK-8 assay results showed that the absorbance values for the old mother group were lower than that of the control group at 48 h and 72 h (P<0.05).
The proportions of cells in the S and G2/M phases of the cell cycle for the older mother group were less than that found for the control group (P<0.05).
Conclusion.
The proliferation rates of hippocampal NSCs seen in the older mother group were lower than that seen in the control group.
American Psychological Association (APA)
Li, Bo& Duan, Ping& Han, Xuefei& Yan, Wenhai& Xing, Ying. 2016. The Effect of Advanced Motherhood on Newborn Offspring’s Hippocampal Neural Stem Cell Proliferation. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098401
Modern Language Association (MLA)
Li, Bo…[et al.]. The Effect of Advanced Motherhood on Newborn Offspring’s Hippocampal Neural Stem Cell Proliferation. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098401
American Medical Association (AMA)
Li, Bo& Duan, Ping& Han, Xuefei& Yan, Wenhai& Xing, Ying. The Effect of Advanced Motherhood on Newborn Offspring’s Hippocampal Neural Stem Cell Proliferation. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098401
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098401