Sundarban Honey Confers Protection against Isoproterenol-Induced Myocardial Infarction in Wistar Rats
Joint Authors
Karim, Nurul
Afroz, Rizwana
Tanvir, E. M.
Khalil, Md. Ibrahim
Alam, Nadia
Hossain, M. Sabir
Gan, Siew Hua
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The present study was designed to investigate the cardioprotective effects of Sundarban honey (SH) in rats with isoproterenol- (ISO-) induced myocardial infarction.
Adult male Wistar Albino rats were pretreated with Sundarban honey (5 g/kg) daily for a period of 6 weeks.
After the treatment period, ISO (85 mg/kg) was subcutaneously injected into the rats at 24 h intervals for 2 days.
ISO-induced myocardial damage was indicated by increased serum cardiac specific troponin I levels and cardiac marker enzyme activities including creatine kinase-MB, lactate dehydrogenase, aspartate transaminase, and alanine transaminase.
Significant increases in serum total cholesterol, triglycerides, and low-density lipoprotein-cholesterol levels were also observed, along with a reduction in the serum high-density lipoprotein-cholesterol level.
In addition to these diagnostic markers, the levels of lipid peroxide products were significantly increased.
The activities of antioxidant enzymes such as superoxide dismutase, glutathione peroxidase, and glutathione reductase were significantly decreased in the hearts after ISO-induced myocardial infarction.
However, pretreatment of ischemic rats with Sundarban honey brought the biochemical parameters to near normalcy, indicating the protective effect of Sundarban honey against ISO-induced ischemia in rats.
Histopathological findings of the heart tissues further confirmed the biochemical findings, indicating that Sundarban honey confers protection against ISO-induced oxidative stress in the myocardium.
American Psychological Association (APA)
Afroz, Rizwana& Tanvir, E. M.& Karim, Nurul& Hossain, M. Sabir& Alam, Nadia& Gan, Siew Hua…[et al.]. 2016. Sundarban Honey Confers Protection against Isoproterenol-Induced Myocardial Infarction in Wistar Rats. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098478
Modern Language Association (MLA)
Afroz, Rizwana…[et al.]. Sundarban Honey Confers Protection against Isoproterenol-Induced Myocardial Infarction in Wistar Rats. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1098478
American Medical Association (AMA)
Afroz, Rizwana& Tanvir, E. M.& Karim, Nurul& Hossain, M. Sabir& Alam, Nadia& Gan, Siew Hua…[et al.]. Sundarban Honey Confers Protection against Isoproterenol-Induced Myocardial Infarction in Wistar Rats. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098478
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098478