Remote Postconditioning Alone and Combined with Hypothermia Improved Postresuscitation Cardiac and Neurological Outcomes in Swine
Joint Authors
Xu, Jiefeng
Huang, Zeng
Ye, Sen
Wang, Moli
Fang, Ya
Li, Zilong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Previously, we demonstrated that remote ischemic postconditioning (RIpostC) improved postresuscitation myocardial and cerebral functions in rat.
Here, we investigated the effects of RIpostC alone and combined with therapeutic hypothermia (TH) on cardiac and neurological outcomes after CPR in swine.
Methods.
Twenty-one pigs were subjected to 10 mins of VF and then 5 mins of CPR.
The animals were randomized to receive RIpostC alone, or its combination with TH, or sham control.
RIpostC was induced by 4 cycles of limb ischemia followed by reperfusion.
TH was implemented by surface cooling to reach a temperature of 32–34°C.
Results.
During 72 hrs after resuscitation, lower level of cardiac troponin I and greater stroke volume and global ejection fraction were observed in animals that received RIpostC when compared to the control.
RIpostC also decreased serum levels of neuron-specific enolase and S100B and increased neurologic alertness score after resuscitation.
The combination of RIpostC and TH resulted in greater improvement in cardiac and neurological outcomes than RIpostC alone.
Conclusion.
RIpostC was conducive to improving postresuscitation myocardial and cerebral functions and reducing their organ injuries.
Its combination with TH further enhanced its protective effects.
American Psychological Association (APA)
Xu, Jiefeng& Huang, Zeng& Ye, Sen& Wang, Moli& Fang, Ya& Li, Zilong. 2016. Remote Postconditioning Alone and Combined with Hypothermia Improved Postresuscitation Cardiac and Neurological Outcomes in Swine. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098539
Modern Language Association (MLA)
Xu, Jiefeng…[et al.]. Remote Postconditioning Alone and Combined with Hypothermia Improved Postresuscitation Cardiac and Neurological Outcomes in Swine. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098539
American Medical Association (AMA)
Xu, Jiefeng& Huang, Zeng& Ye, Sen& Wang, Moli& Fang, Ya& Li, Zilong. Remote Postconditioning Alone and Combined with Hypothermia Improved Postresuscitation Cardiac and Neurological Outcomes in Swine. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098539