The Impact of Biopsy on Human Embryo Developmental Potential during Preimplantation Genetic Diagnosis
Joint Authors
Ubaldi, Filippo
Cimadomo, Danilo
Capalbo, Antonio
Scarica, Catello
Palagiano, Antonio
Canipari, Rita
Rienzi, Laura
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Preimplantation Genetic Diagnosis and Screening (PGD/PGS) for monogenic diseases and/or numerical/structural chromosomal abnormalities is a tool for embryo testing aimed at identifying nonaffected and/or euploid embryos in a cohort produced during an IVF cycle.
A critical aspect of this technology is the potential detrimental effect that the biopsy itself can have upon the embryo.
Different embryo biopsy strategies have been proposed.
Cleavage stage blastomere biopsy still represents the most commonly used method in Europe nowadays, although this approach has been shown to have a negative impact on embryo viability and implantation potential.
Polar body biopsy has been proposed as an alternative to embryo biopsy especially for aneuploidy testing.
However, to date no sufficiently powered study has clarified the impact of this procedure on embryo reproductive competence.
Blastocyst stage biopsy represents nowadays the safest approach not to impact embryo implantation potential.
For this reason, as well as for the evidences of a higher consistency of the molecular analysis when performed on trophectoderm cells, blastocyst biopsy implementation is gradually increasing worldwide.
The aim of this review is to present the evidences published to date on the impact of the biopsy at different stages of preimplantation development upon human embryos reproductive potential.
American Psychological Association (APA)
Cimadomo, Danilo& Capalbo, Antonio& Ubaldi, Filippo& Scarica, Catello& Palagiano, Antonio& Canipari, Rita…[et al.]. 2016. The Impact of Biopsy on Human Embryo Developmental Potential during Preimplantation Genetic Diagnosis. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098739
Modern Language Association (MLA)
Cimadomo, Danilo…[et al.]. The Impact of Biopsy on Human Embryo Developmental Potential during Preimplantation Genetic Diagnosis. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1098739
American Medical Association (AMA)
Cimadomo, Danilo& Capalbo, Antonio& Ubaldi, Filippo& Scarica, Catello& Palagiano, Antonio& Canipari, Rita…[et al.]. The Impact of Biopsy on Human Embryo Developmental Potential during Preimplantation Genetic Diagnosis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098739
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098739