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Diagnosis of Human Axillary Osmidrosis by Genotyping of the Human ABCC11 Gene: Clinical Practice and Basic Scientific Evidence
Joint Authors
Nakagawa, Hiroshi
Toyoda, Yu
Gomi, Tsuneaki
Nagakura, Makoto
Ishikawa, Toshihisa
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The importance of personalized medicine and healthcare is becoming increasingly recognized.
Genetic polymorphisms associated with potential risks of various human genetic diseases as well as drug-induced adverse reactions have recently been well studied, and their underlying molecular mechanisms are being uncovered by functional genomics as well as genome-wide association studies.
Knowledge of certain genetic polymorphisms is clinically important for our understanding of interindividual differences in drug response and/or disease risk.
As such evidence accumulates, new clinical applications and practices are needed.
In this context, the development of new technologies for simple, fast, accurate, and cost-effective genotyping is imperative.
Here, we describe a simple isothermal genotyping method capable of detecting single nucleotide polymorphisms (SNPs) in the human ATP-binding cassette (ABC) transporter ABCC11 gene and its application to the clinical diagnosis of axillary osmidrosis.
We have recently reported that axillary osmidrosis is linked with one SNP 538G>A in the ABCC11 gene.
Our molecular biological and biochemical studies have revealed that this SNP greatly affects the protein expression level and the function of ABCC11.
In this review, we highlight the clinical relevance and importance of this diagnostic strategy in axillary osmidrosis therapy.
American Psychological Association (APA)
Toyoda, Yu& Gomi, Tsuneaki& Nakagawa, Hiroshi& Nagakura, Makoto& Ishikawa, Toshihisa. 2016. Diagnosis of Human Axillary Osmidrosis by Genotyping of the Human ABCC11 Gene: Clinical Practice and Basic Scientific Evidence. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098847
Modern Language Association (MLA)
Toyoda, Yu…[et al.]. Diagnosis of Human Axillary Osmidrosis by Genotyping of the Human ABCC11 Gene: Clinical Practice and Basic Scientific Evidence. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098847
American Medical Association (AMA)
Toyoda, Yu& Gomi, Tsuneaki& Nakagawa, Hiroshi& Nagakura, Makoto& Ishikawa, Toshihisa. Diagnosis of Human Axillary Osmidrosis by Genotyping of the Human ABCC11 Gene: Clinical Practice and Basic Scientific Evidence. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098847
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098847