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Development of a Murine Infection Model with Leishmania killicki, Responsible for Cutaneous Leishmaniosis in Algeria: Application in Pharmacology
Joint Authors
Eddaikra, Naouel
Kherachi Djenad, Ihcene
Benbetka, Sihem
Benikhlef, Razika
Aït-Oudhia, Khatima
Moulti-Mati, Farida
Oury, Bruno
Sereno, Denis
Harrat, Zoubir
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In Algeria, Leishmania infantum, Leishmania major, and Leishmania killicki (Leishmania tropica) are responsible for cutaneous leishmaniosis.
We established a murine model of L.
killicki infection to investigate its infective capacity, some immunophysiopathological aspects, and its suitability for pharmacological purposes.
Following the injection of L.
major or L.
killicki metacyclic promastigotes in the ear dermis of BALB/c mice, the course of infection was followed.
The infection with L.
killicki caused slower lesion formation than with L.
major.
The presence of L.
killicki or L.
major DNA and parasites was detected in the ear dermis and in lymph nodes, spleen, and liver.
Lesions induced by L.
killicki were nonulcerative in their aspect, whereas those caused by L.
major were highly ulcerative and necrotic, which matches well with the lesion phenotype reported in humans for L.
killicki and L.
major, respectively.
The treatment of L.
killicki lesions by injection of Glucantime® significantly reduced the lesion thickness and parasite burden.
Ear dermal injection of BALB/c mice constitutes a model to study lesions physiopathology caused by L.
killicki and presents interest for in vivo screening of new compounds against this pathogen, emerging in Algeria.
American Psychological Association (APA)
Eddaikra, Naouel& Kherachi Djenad, Ihcene& Benbetka, Sihem& Benikhlef, Razika& Aït-Oudhia, Khatima& Moulti-Mati, Farida…[et al.]. 2016. Development of a Murine Infection Model with Leishmania killicki, Responsible for Cutaneous Leishmaniosis in Algeria: Application in Pharmacology. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098901
Modern Language Association (MLA)
Eddaikra, Naouel…[et al.]. Development of a Murine Infection Model with Leishmania killicki, Responsible for Cutaneous Leishmaniosis in Algeria: Application in Pharmacology. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098901
American Medical Association (AMA)
Eddaikra, Naouel& Kherachi Djenad, Ihcene& Benbetka, Sihem& Benikhlef, Razika& Aït-Oudhia, Khatima& Moulti-Mati, Farida…[et al.]. Development of a Murine Infection Model with Leishmania killicki, Responsible for Cutaneous Leishmaniosis in Algeria: Application in Pharmacology. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098901