Polymorphisms in DNA Repair Gene XRCC3 and Susceptibility to Breast Cancer in Saudi Females
Joint Authors
Ali Khan Pathan, Akbar
Alanazi, Mohammed
Alabdulkarim, Huda A.
Alamri, Abdullah
Ali, Alaa Mohammed
Purusottapatnam Shaik, Jilani
Warsy, Arjumand
Reddy Parine, Narasimha
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We investigated three common polymorphisms (SNPs) in the XRCC3 gene (rs861539, rs1799794, and rs1799796) in 143 Saudi females suffering from breast cancer (median age = 51.4 years) and 145 age matched normal healthy controls.
DNA was extracted from whole blood and genotyping was conducted using PCR-RFLP.
rs1799794 showed significant association, where AA and AA+AG occurred at a significantly higher frequency in the cancer patients compared to the control group (OR: 28.1; 95% CI: 3.76–21.12; χ 2 : 22.82; p < 0.0001 ).
The G allele was protective and presented with a dominant model.
The genotype and allele frequencies of rs861539 C>T and rs1799796 A>G did not show a significant difference when the results in the patients and controls were compared.
However, the frequency of rs1799796 differed significantly in patients with different age of diagnosis, tumor grade, and ER and HER2 status.
The wild type A allele occurred at a higher frequency in the ER− and HER2− group.
Our results among Saudis suggest that some variations in XRCC3 may contribute to breast cancer susceptibility.
In conclusion, the results obtained during this study suggest that rs1799794 in XRCC3 shows strong association with breast cancer development in Saudi females.
American Psychological Association (APA)
Ali, Alaa Mohammed& Alabdulkarim, Huda A.& Alanazi, Mohammed& Reddy Parine, Narasimha& Purusottapatnam Shaik, Jilani& Alamri, Abdullah…[et al.]. 2016. Polymorphisms in DNA Repair Gene XRCC3 and Susceptibility to Breast Cancer in Saudi Females. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099128
Modern Language Association (MLA)
Ali, Alaa Mohammed…[et al.]. Polymorphisms in DNA Repair Gene XRCC3 and Susceptibility to Breast Cancer in Saudi Females. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1099128
American Medical Association (AMA)
Ali, Alaa Mohammed& Alabdulkarim, Huda A.& Alanazi, Mohammed& Reddy Parine, Narasimha& Purusottapatnam Shaik, Jilani& Alamri, Abdullah…[et al.]. Polymorphisms in DNA Repair Gene XRCC3 and Susceptibility to Breast Cancer in Saudi Females. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099128
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099128