Validation of the Model of End-Stage Liver Disease for Liver Transplant Allocation in Alberta: Implications for Future Directions in Canada
Joint Authors
Burak, Kelly W.
Meeberg, Glenda A.
Myers, Robert P.
Fick, Gordon H.
Swain, Mark G.
Bain, Vincent G.
Kneteman, Norman M.
Hilsden, Robert J.
Source
Canadian Journal of Gastroenterology and Hepatology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Since 2002, the Model of End-Stage Liver Disease (MELD) has been used for allocation of liver transplants (LT) in the USA.
In Canada, livers were allocated by the CanWAIT algorithm.
The aim of this study was to compare the abilities of MELD, Child-Pugh (CP), and CanWAIT status to predict 3-month and 1-year mortality before LT in Canadian patients and to describe the use of MELD in Canada.
Methods.
Validation of MELD was performed in 320 patients listed for LT in Alberta (1998–2002).
In October 2014, a survey of MELD use by Canadian LT centers was conducted.
Results.
Within 1 year of listing, 47 patients were removed from the waiting list (29 deaths, 18 too ill for LT).
Using logistic regression, the MELD and CP were better than the CanWAIT at predicting 3-month (AUROC: 0.79, 0.78, and 0.59; p = 0.0002 ) and 1-year waitlist mortality (AUROC: 0.70, 0.70, and 0.55; p = 0.0023 ).
Beginning in 2004, MELD began to be adopted by Canadian LT programs but its use was not standardized.
Conclusions.
Compared with the CanWAIT system, the MELD score was significantly better at predicting LT waitlist mortality.
MELD-sodium (MELD-Na) has now been adopted for LT allocation in Canada.
American Psychological Association (APA)
Burak, Kelly W.& Meeberg, Glenda A.& Myers, Robert P.& Fick, Gordon H.& Swain, Mark G.& Bain, Vincent G.…[et al.]. 2016. Validation of the Model of End-Stage Liver Disease for Liver Transplant Allocation in Alberta: Implications for Future Directions in Canada. Canadian Journal of Gastroenterology and Hepatology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099836
Modern Language Association (MLA)
Burak, Kelly W.…[et al.]. Validation of the Model of End-Stage Liver Disease for Liver Transplant Allocation in Alberta: Implications for Future Directions in Canada. Canadian Journal of Gastroenterology and Hepatology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1099836
American Medical Association (AMA)
Burak, Kelly W.& Meeberg, Glenda A.& Myers, Robert P.& Fick, Gordon H.& Swain, Mark G.& Bain, Vincent G.…[et al.]. Validation of the Model of End-Stage Liver Disease for Liver Transplant Allocation in Alberta: Implications for Future Directions in Canada. Canadian Journal of Gastroenterology and Hepatology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099836