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Human Papilloma Virus Persistence after Cone Excision in Women with Cervical High Grade Squamous Intraepithelial Lesion: A Prospective Study
Joint Authors
Pirtea, Laurențiu
Grigoraş, Dorin
Matusz, Petru
Pirtea, Marilena
Moleriu, Lavinia
Tudor, Anca
Ilina, Răzvan
Secoşan, Cristina
Horhat, Florin
Mazilu, Octavian
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Persistent human papillomavirus (HPV) infection is a necessary event in cervical cancer tumorigenesis.
Our objectives were to estimate the rate of HPV infection persistence after large loop excision of the transformation zone (LEEP) in patients with high grade squamous intraepithelial lesions (HSIL) and to investigate if HPV persistence is type related.
Methods.
We conducted a prospective study on 89 patients with HSIL treated with LEEP.
DNA HPV was performed before surgery and at 6, 12, and 18 months after LEEP.
Results.
Four patients were excluded from the study.
The HPV persistence in the remaining 85 patients was 32.95% (6 months), 14.12% (12 months), and 10.59% (18 months).
Type 16 had the highest persistence rate, 23.5% (6 months), 11.8% (12 months), and 8.2% (18 months).
Coinfection was found to be 54.12% before LEEP and 18.8% (6 months), 4.7% (12 months), and 3.5% (18 months) after LEEP.
The rate of coinfections including type 16 was 46.83% of all coinfections.
Coinfection including type 16 was not correlated with higher persistence rate compared to infection with type 16 only.
Conclusions.
HPV infection is not completely eradicated by LEEP in patients with HSIL lesion on PAP smear.
HPV persistence after LEEP is influenced by HPV type.
HPV type 16 has the highest persistence rate.
American Psychological Association (APA)
Pirtea, Laurențiu& Grigoraş, Dorin& Matusz, Petru& Pirtea, Marilena& Moleriu, Lavinia& Tudor, Anca…[et al.]. 2016. Human Papilloma Virus Persistence after Cone Excision in Women with Cervical High Grade Squamous Intraepithelial Lesion: A Prospective Study. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099981
Modern Language Association (MLA)
Pirtea, Laurențiu…[et al.]. Human Papilloma Virus Persistence after Cone Excision in Women with Cervical High Grade Squamous Intraepithelial Lesion: A Prospective Study. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1099981
American Medical Association (AMA)
Pirtea, Laurențiu& Grigoraş, Dorin& Matusz, Petru& Pirtea, Marilena& Moleriu, Lavinia& Tudor, Anca…[et al.]. Human Papilloma Virus Persistence after Cone Excision in Women with Cervical High Grade Squamous Intraepithelial Lesion: A Prospective Study. Canadian Journal of Infectious Diseases and Medical Microbiology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099981
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099981