Antibiotic Utilization Patterns in Patients with Ventilator-Associated Pneumonia: A Canadian Context
Joint Authors
Chin, Tracy
Kushner, Barry
Dersch-Mills, Deonne
Zuege, Danny J.
Source
Canadian Journal of Infectious Diseases and Medical Microbiology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This retrospective cohort study describes the patterns of antibiotic use for the treatment of ventilator-associated pneumonia (VAP) in the Calgary Zone of Alberta Health Services.
Timing, appropriateness, and duration of antibiotics were evaluated in two hundred consecutive cases of VAP derived from 4 adult intensive care units (ICU).
Antibiotic therapy was initiated in less than 24 hours from VAP diagnosis in 83% of cases.
Although most patients (89%) received empiric therapy that demonstrated in vitro sensitivity to the identified pathogens, only 24% of cases were congruent with the 2008 Association of Medical Microbiology and Infectious Disease (AMMI) guidelines.
Both ICU ( p = 0.001 ) and hospital ( p = 0.015 ) mortality were significantly lower and there was a trend for shorter ICU length of stay ( p = 0.051 ) in patients who received appropriate versus inappropriate initial antibiotics.
There were no outcome differences related to compliance with AMMI guidelines.
This exploratory study provides insight into the use of antimicrobials for the treatment of VAP in a large Canadian health region.
The discordance between the assessments of appropriateness of empiric therapy based on recovered pathogens versus AMMI guidelines is notable, emphasizing the importance of using as much as possible local microbiologic and antimicrobial resistance data.
American Psychological Association (APA)
Chin, Tracy& Kushner, Barry& Dersch-Mills, Deonne& Zuege, Danny J.. 2016. Antibiotic Utilization Patterns in Patients with Ventilator-Associated Pneumonia: A Canadian Context. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099986
Modern Language Association (MLA)
Chin, Tracy…[et al.]. Antibiotic Utilization Patterns in Patients with Ventilator-Associated Pneumonia: A Canadian Context. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1099986
American Medical Association (AMA)
Chin, Tracy& Kushner, Barry& Dersch-Mills, Deonne& Zuege, Danny J.. Antibiotic Utilization Patterns in Patients with Ventilator-Associated Pneumonia: A Canadian Context. Canadian Journal of Infectious Diseases and Medical Microbiology. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099986
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099986