Clival Ectopic Pituitary Adenoma Mimicking a Chordoma: Case Report and Review of the Literature
Joint Authors
Bendok, B. R.
Karras, Constantine L.
Abecassis, Isaac Josh
Abecassis, Zachary A.
Adel, Joseph G.
Bit-Ivan, Esther N.
Chandra, Rakesh K.
Source
Case Reports in Neurological Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Purely ectopic pituitary adenomas are exceedingly rare.
Here we report on a patient that presented with an incidental clival mass thought to be a chordoma.
Endonasal resection, tumor pathology, and endocrinology workup revealed a prolactinoma.
Case Presentation.
A 41-year-old male presented with an incidental clival lesion presumed to be a chordoma.
On MRI it involved the entire clivus, extended laterally to the petroclival junction, and invaded the cavernous sinuses bilaterally, encasing both internal carotid arteries, without direct extension into the sella.
Intraoperatively, it was clear that the tumor originated from the clivus and that the sellar dura was completely intact.
Frozen-section pathology was consistent with a pituitary adenoma.
Immunostaining was positive for synaptophysin and prolactin with a low Ki-67 index, suggestive of a prolactinoma.
Additional immunohistochemical stains seen in chordomas (EMA, S100, and Brachyury) and other metastatic tumors were negative.
A postoperative endocrine workup revealed an elevated serum prolactin of 881.3 ng/mL (normal < 20).
Conclusions.
In conclusion, it is crucial to maintain an extensive differential diagnosis when evaluating a patient with a clival lesion.
Ectopic clival pituitary adenomas, although rare, may warrant an endocrinological workup preoperatively as the majority may respond to medical treatment.
American Psychological Association (APA)
Karras, Constantine L. & Abecassis, Isaac Josh & Abecassis, Zachary A.& Adel, Joseph G.& Bit-Ivan, Esther N. & Chandra, Rakesh K.…[et al.]. 2016. Clival Ectopic Pituitary Adenoma Mimicking a Chordoma: Case Report and Review of the Literature. Case Reports in Neurological Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1101325
Modern Language Association (MLA)
Karras, Constantine L.…[et al.]. Clival Ectopic Pituitary Adenoma Mimicking a Chordoma: Case Report and Review of the Literature. Case Reports in Neurological Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1101325
American Medical Association (AMA)
Karras, Constantine L. & Abecassis, Isaac Josh & Abecassis, Zachary A.& Adel, Joseph G.& Bit-Ivan, Esther N. & Chandra, Rakesh K.…[et al.]. Clival Ectopic Pituitary Adenoma Mimicking a Chordoma: Case Report and Review of the Literature. Case Reports in Neurological Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1101325
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1101325