Safety and Efficacy of Intrapleural Tissue Plasminogen Activator and DNase during Extended Use in Complicated Pleural Space Infections
Joint Authors
McClune, Jason R.
Wilshire, Candice L.
Gorden, Jed A.
Louie, Brian E.
Farviar, Alexander S.
Stefanski, Michael J.
Vallieres, Eric
Aye, Ralph W.
Gilbert, Christopher R.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The use of intrapleural therapy with tissue plasminogen activator and DNase improves outcomes in patients with complicated pleural space infections.
However, little data exists for the use of combination intrapleural therapy after the initial dosing period of six doses.
We sought to describe the safety profile and outcomes of intrapleural therapy beyond this standard dosing.
A retrospective review of patients receiving intrapleural therapy with tissue plasminogen activator and DNase was performed at two institutions.
We identified 101 patients from January 2013 to August 2015 receiving intrapleural therapy for complicated pleural space infection.
The extended use of intrapleural tissue plasminogen activator and DNase therapy beyond six doses was utilized in 20% (20/101) of patients.
The mean number of doses in those undergoing extended dosing was 9.8 (range of 7–16).
Within the population studied there appears to be no statistically significant increased risk of complications, need for surgical referral, or outcome differences when comparing those receiving standard or extended dosing intrapleural therapy.
Future prospective study of intrapleural therapy as an alternative option for patients who fail initial pleural drainage and are unable to tolerate/accept a surgical intervention appears a potential area of study.
American Psychological Association (APA)
McClune, Jason R.& Wilshire, Candice L.& Gorden, Jed A.& Louie, Brian E.& Farviar, Alexander S.& Stefanski, Michael J.…[et al.]. 2016. Safety and Efficacy of Intrapleural Tissue Plasminogen Activator and DNase during Extended Use in Complicated Pleural Space Infections. Canadian Respiratory Journal،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103268
Modern Language Association (MLA)
McClune, Jason R.…[et al.]. Safety and Efficacy of Intrapleural Tissue Plasminogen Activator and DNase during Extended Use in Complicated Pleural Space Infections. Canadian Respiratory Journal No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1103268
American Medical Association (AMA)
McClune, Jason R.& Wilshire, Candice L.& Gorden, Jed A.& Louie, Brian E.& Farviar, Alexander S.& Stefanski, Michael J.…[et al.]. Safety and Efficacy of Intrapleural Tissue Plasminogen Activator and DNase during Extended Use in Complicated Pleural Space Infections. Canadian Respiratory Journal. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103268
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103268