Role of Neutrophil Gelatinase-Associated Lipocalin in the Diagnosis and Early Treatment of Acute Kidney Injury in a Case Series of Patients with Acute Decompensated Heart Failure: A Case Series
Joint Authors
Angeletti, Silvia
Lo Presti, Alessandra
Dicuonzo, Giordano
De Cesaris, Marina
Fogolari, Marta
Ciccozzi, Massimo
Morolla, Davide
Capone, Federico
Costantino, Sebastiano
Spoto, Silvia
Source
Cardiology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Patients with acute decompensated heart failure (ADHF) frequently develop worsening in renal function until Acute Kidney Injury (AKI).
The use of kidney injury biomarkers could be useful in the early diagnosis of AKI.
In the present study, the role of the neutrophil gelatinase-associated lipocalin (NGAL), compared to the standard creatinine, in ADHF patients, was analyzed to evaluate if an early treatment could affect the outcome.
A case series of 24 ADHF patients was enrolled and patients randomly divided in two groups (Group A and Group B).
In Group A, NGAL, creatinine, and eGFR were measured, while in Group B, creatinine and eGFR alone were measured.
NGAL was measured by turbidimetric immunoassay and creatinine using an enzymatic spectrophotometric method.
In presence of AKI, creatinine increase and eGFR decrease were significantly lower in Group A than in Group B, whereas in absence of AKI the difference between the two groups was not significant.
Hospitalization stay was significantly lower in Group A (receiving early treatment based on NGAL) than in Group B.
In ADHF patients, plasma NGAL in combination with creatinine was superior to the standard creatinine in the diagnosis and early treatment of AKI with a better outcome and a decreased hospital stay.
American Psychological Association (APA)
Angeletti, Silvia& Fogolari, Marta& Morolla, Davide& Capone, Federico& Costantino, Sebastiano& Spoto, Silvia…[et al.]. 2016. Role of Neutrophil Gelatinase-Associated Lipocalin in the Diagnosis and Early Treatment of Acute Kidney Injury in a Case Series of Patients with Acute Decompensated Heart Failure: A Case Series. Cardiology Research and Practice،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103281
Modern Language Association (MLA)
Angeletti, Silvia…[et al.]. Role of Neutrophil Gelatinase-Associated Lipocalin in the Diagnosis and Early Treatment of Acute Kidney Injury in a Case Series of Patients with Acute Decompensated Heart Failure: A Case Series. Cardiology Research and Practice No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103281
American Medical Association (AMA)
Angeletti, Silvia& Fogolari, Marta& Morolla, Davide& Capone, Federico& Costantino, Sebastiano& Spoto, Silvia…[et al.]. Role of Neutrophil Gelatinase-Associated Lipocalin in the Diagnosis and Early Treatment of Acute Kidney Injury in a Case Series of Patients with Acute Decompensated Heart Failure: A Case Series. Cardiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103281
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103281