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Elevated Omentin Serum Levels Predict Long-Term Survival in Critically Ill Patients
Joint Authors
Koch, Alexander
Benz, Fabian
Roderburg, Christoph
Luedde, Mark
Niedeggen, Jennifer
Vucur, Mihael
Hippe, Hans-Joerg
Spehlmann, Martina E.
Schueller, Florian
Loosen, Sven
Frey, Norbert
Luedde, Tom
Trautwein, Christian
Tacke, Frank
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Introduction.
Omentin, a recently described adipokine, was shown to be involved in the pathophysiology of inflammatory and infectious diseases.
However, its role in critical illness and sepsis is currently unknown.
Materials and Methods.
Omentin serum concentrations were measured in 117 ICU-patients (84 with septic and 33 with nonseptic disease etiology) admitted to the medical ICU.
Results were compared with 50 healthy controls.
Results.
Omentin serum levels of critically ill patients at admission to the ICU or after 72 hours of ICU treatment were similar compared to healthy controls.
Moreover, circulating omentin levels were independent of sepsis and etiology of critical illness.
Notably, serum concentrations of omentin could not be linked to concentrations of inflammatory cytokines or routinely used sepsis markers.
While serum levels of omentin were not predictive for short term survival during ICU treatment, low omentin concentrations were an independent predictor of patients’ overall survival.
Omentin levels strongly correlated with that of other adipokines (e.g., leptin receptor or adiponectin), which have also been identified as prognostic markers in critical illness.
Conclusions.
Although circulating omentin levels did not differ between ICU-patients and controls, elevated omentin levels were predictive for an impaired patients’ long term survival.
American Psychological Association (APA)
Luedde, Mark& Benz, Fabian& Niedeggen, Jennifer& Vucur, Mihael& Hippe, Hans-Joerg& Spehlmann, Martina E.…[et al.]. 2016. Elevated Omentin Serum Levels Predict Long-Term Survival in Critically Ill Patients. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103681
Modern Language Association (MLA)
Luedde, Mark…[et al.]. Elevated Omentin Serum Levels Predict Long-Term Survival in Critically Ill Patients. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103681
American Medical Association (AMA)
Luedde, Mark& Benz, Fabian& Niedeggen, Jennifer& Vucur, Mihael& Hippe, Hans-Joerg& Spehlmann, Martina E.…[et al.]. Elevated Omentin Serum Levels Predict Long-Term Survival in Critically Ill Patients. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103681
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103681