Circulating Omentin-1 Levels Are Decreased in Dilated Cardiomyopathy Patients with Overt Heart Failure

Abstract EN

Background.

Recent evidence demonstrated that the circulating levels of omentin-1 are related to the presence of ischemic heart disease and heart failure.

However, omentin-1 plasma levels in patients with nonischemic dilated cardiomyopathy (DCM), which is the most common etiology of heart failure, have yet to be investigated.

Methods.

Plasma levels of omentin-1 and adiponectin were measured in 100 patients with DCM and 45 healthy controls.

Results.

Plasma omentin-1 levels significantly decreased in DCM patients compared with the control group, whereas adiponectin levels significantly increased in DCM patients compared with the control group.

Plasma omentin-1 levels were negatively correlated with adiponectin ( R = - 0.376 , P = 0.005 ), C-reactive protein (CRP) ( R = - 0.320 , P = 0.001 ), and N-terminal pro-brain natriuretic peptide (NT-proBNP) ( R = - 0.365 , P = 0.000 ) levels as well as left ventricular end-diastolic diameter (LVEDD) ( R = - 0.200 , P = 0.046 ) but were positively correlated with left ventricular ejection fraction (LVEF) ( R = 0.496 , P = 0.000 ).

Plasma adiponectin levels were positively correlated with CRP ( R = 0.273 , P = 0.006 ) and NT-proBNP ( R = 0.329 , P = 0.001 ) levels but were negatively correlated with fasting glucose ( R = - 0.218 , P = 0.029 ) and LVEF ( R = - 0.615 , P = 0.000 ) levels.

Furthermore, omentin-1 (OR 0.983, 95% CI 0.970 to 0.996; P = 0.008 ) levels were independently associated with the presence of DCM before NT-proBNP was added.

Conclusions.

Omentin-1 is a novel biomarker of DCM.