Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses
Joint Authors
Zhou, Qiaozhen
Zhu, Li
Zhang, Dafeng
Li, Ning
Li, Qiao
Dai, Panpan
Mao, Yixin
Li, Xumin
Ma, Jianfeng
Huang, Shengbin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Numerous studies suggested that oxidative stress (OS) played a central role in the onset and development of postmenopausal osteoporosis (PO); however, conflicting results were obtained as to the association of OS-related biomarkers and PO.
This meta-analysis aimed to identify the association between these markers and PO, and explore factors that may explain the inconsistencies in these results.
A systematic literature search was conducted in relevant database.
Search terms and selection criteria were priorly determined to identify and include all studies that detected markers of OS in PO patients.
We pooled data with a random effects meta-analysis with standardized mean differences and 95% confidence interval.
Total 17 studies including 12 OS markers were adopted.
The results showed that superoxide dismutase (SOD) in erythrocytes, catalase (CAT), total antioxidant status (TAS), hydroperoxides (HY), advanced oxidation protein products (AOPP), malondialdehyde (MDA), and vitamin B12 (VB12) in plasma/serum were not statistically different between the PO and control group, whereas significantly increased level of homocysteine (Hcy) and nitric oxide (NO), along with decreased SOD, glutathione peroxidase (GPx), folate, and total antioxidant power (TAP) in plasma/serum were obtained in the PO group.
In summary, OS might serve as potential biomarkers in the etiopathophysiology and clinical course of PO.
American Psychological Association (APA)
Zhou, Qiaozhen& Zhu, Li& Zhang, Dafeng& Li, Ning& Li, Qiao& Dai, Panpan…[et al.]. 2016. Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses. Disease Markers،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1103751
Modern Language Association (MLA)
Zhou, Qiaozhen…[et al.]. Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses. Disease Markers No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1103751
American Medical Association (AMA)
Zhou, Qiaozhen& Zhu, Li& Zhang, Dafeng& Li, Ning& Li, Qiao& Dai, Panpan…[et al.]. Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1103751
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103751