Galectin-3 Reflects Mitral Annular Plane Systolic Excursion Being Assessed by Cardiovascular Magnetic Resonance Imaging
Joint Authors
Hoffmann, Ursula
Akin, Ibrahim
Henzler, Thomas
Papavassiliu, Theano
Kim, Seung-Hyun
Behnes, Michael
Natale, Michele
Hoffmann, Julia
Reckord, Nadine
Budjan, Johannes
Borggrefe, Martin
Bertsch, Thomas
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
This study investigates whether serum levels of galectin-3 may reflect impaired mitral annular plane systolic excursion (MAPSE) in patients undergoing cardiac magnetic resonance imaging (cMRI).
Methods.
Patients undergoing cMRI during routine clinical care were included prospectively within an all-comers design.
Blood samples for biomarker measurements were collected within 24 hours following cMRI.
Statistical analyses were performed in all patients and in three subgroups according to MAPSE (MAPSE I: ≥11 mm, MAPSE II: ≥8 mm–<11 mm, and MAPSE III: <8 mm).
Patients with right ventricular dysfunction (<50%) were excluded.
Results.
84 patients were included in the study.
Median LVEF was 59% (IQR 51–64%).
Galectin-3 correlated significantly with NT-proBNP (r=0.42, p=0.0001).
Galectin-3 increased significantly according to the different stages of impaired MAPSE (p=0.006) and was able to discriminate both patients with impaired MAPSE <11 mm (area under the curve (AUC) = 0.645, p=0.024) and <8 mm (AUC = 0.733, p=0.003).
Combining galectin-3 with NT-proBNP improved discrimination of MAPSE <8 mm (AUC 0.803, p=0.0001).
In multivariable logistic regression models galectin-3 was still associated with impaired MAPSE (MAPSE < 11 mm: odds ratio (OR) = 3.53, p=0.018; MAPSE < 8 mm: OR = 3.18, p=0.06).
Conclusions.
Galectin-3 reflects MAPSE being assessed by cardiac MRI.
American Psychological Association (APA)
Kim, Seung-Hyun& Behnes, Michael& Natale, Michele& Hoffmann, Julia& Reckord, Nadine& Hoffmann, Ursula…[et al.]. 2016. Galectin-3 Reflects Mitral Annular Plane Systolic Excursion Being Assessed by Cardiovascular Magnetic Resonance Imaging. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103761
Modern Language Association (MLA)
Kim, Seung-Hyun…[et al.]. Galectin-3 Reflects Mitral Annular Plane Systolic Excursion Being Assessed by Cardiovascular Magnetic Resonance Imaging. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103761
American Medical Association (AMA)
Kim, Seung-Hyun& Behnes, Michael& Natale, Michele& Hoffmann, Julia& Reckord, Nadine& Hoffmann, Ursula…[et al.]. Galectin-3 Reflects Mitral Annular Plane Systolic Excursion Being Assessed by Cardiovascular Magnetic Resonance Imaging. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103761