The Relationship between Serum Endocan Levels and Depression in Alzheimer’s Disease
Joint Authors
Kim, SoYeon
Yoon, KyungHee
Roh, Daeyoung
Kim, DoHoon
Moon, Yoo Sun
Lee, Sang Kyu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
Growing evidence suggests that angiogenic vascular factors may be involved in the pathogenic mechanism of Alzheimer’s disease (AD), and recently endocan has been proposed as an angiogenic biomarker.
The aim of this study was to measure serum endocan levels according to the presence of depression in AD and to investigate the association among the serum endocan levels, cognitive function, and depression in these patients.
Methods.
Serum endocan levels were measured in 26 AD patients with depression, 29 AD patients without depression, and 29 healthy controls using an enzyme-linked immunosorbent assay kit.
The Mini-Mental State Examination-Korean version (MMSE-KC) and the Korean version of the Geriatric Depression Scale-Short Form (SGDS-K) were used to evaluate cognitive function and depressive symptoms, respectively.
Results.
Serum endocan levels were significantly lower in AD patients with depression than in AD patients without depression or healthy controls.
Serum endocan levels were negatively correlated with SGDS-K scores but not with MMSE-KC scores in AD patients.
Conclusions.
This study suggests that serum endocan levels might be associated with depression in AD.
Future studies are needed to investigate the pathophysiological mechanisms or the role of endocan in AD with depression.
American Psychological Association (APA)
Yoon, KyungHee& Kim, SoYeon& Moon, Yoo Sun& Roh, Daeyoung& Lee, Sang Kyu& Kim, DoHoon. 2016. The Relationship between Serum Endocan Levels and Depression in Alzheimer’s Disease. Disease Markers،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103785
Modern Language Association (MLA)
Yoon, KyungHee…[et al.]. The Relationship between Serum Endocan Levels and Depression in Alzheimer’s Disease. Disease Markers No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1103785
American Medical Association (AMA)
Yoon, KyungHee& Kim, SoYeon& Moon, Yoo Sun& Roh, Daeyoung& Lee, Sang Kyu& Kim, DoHoon. The Relationship between Serum Endocan Levels and Depression in Alzheimer’s Disease. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103785
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103785