A Comparison between the Effects of Glucantime, Topical Trichloroacetic Acid 50% plus Glucantime, and Fractional Carbon Dioxide Laser plus Glucantime on Cutaneous Leishmaniasis Lesions
Joint Authors
Siadat, Amir Hossein
Jaffary, Fariba
Nilforoushzadeh, Mohammad Ali
Haftbaradaran, Elaheh
Ansari, Nazli
Kheirkhah, Abbas
Source
Dermatology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-11
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Cutaneous leishmaniasis is an endemic disease in Iran.
Pentavalent antimonial drugs have been the first line of therapy in cutaneous leishmaniasis for many years.
However, the cure rate of these agents is still not favorable.
This study was carried out to compare the efficacies of intralesional glucantime with topical trichloroacetic acid 50% (TCA 50%) + glucantime and fractional carbon dioxide laser + glucantime in the treatment of cutaneous leishmaniasis.
Methods.
A total of 90 patients were randomly divided into three groups of 30 to be treated with intralesional injection of glucantime, a combination of topical TCA 50% and glucantime, or a combination of fractional laser and glucantime.
The overall clinical improvement and changes in sizes of lesions and scars were assessed and compared among three groups.
Results.
The mean duration of treatment was 6.1 ± 2.1 weeks in all patients (range: 2–12 weeks) and 6.8 ± 1.7 , 5.2 ± 1.0 , and 6.3 ± 3.0 weeks in glucantime, topical TCA plus glucantime, and fractional laser plus glucantime groups, respectively ( P = 0.011 ).
Complete improvement was observed in 10 (38.5%), 27 (90%), and 20 (87%) patients of glucantime, glucantime + TCA, and glucantime + laser groups, respectively ( P < 0.001 ).
Conclusion.
Compared to glucantime alone, the combination of intralesional glucantime and TCA 50% or fractional CO2 laser had significantly higher and faster cure rate in patients with cutaneous leishmaniasis.
American Psychological Association (APA)
Jaffary, Fariba& Nilforoushzadeh, Mohammad Ali& Siadat, Amir Hossein& Haftbaradaran, Elaheh& Ansari, Nazli& Kheirkhah, Abbas. 2016. A Comparison between the Effects of Glucantime, Topical Trichloroacetic Acid 50% plus Glucantime, and Fractional Carbon Dioxide Laser plus Glucantime on Cutaneous Leishmaniasis Lesions. Dermatology Research and Practice،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1103845
Modern Language Association (MLA)
Jaffary, Fariba…[et al.]. A Comparison between the Effects of Glucantime, Topical Trichloroacetic Acid 50% plus Glucantime, and Fractional Carbon Dioxide Laser plus Glucantime on Cutaneous Leishmaniasis Lesions. Dermatology Research and Practice No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1103845
American Medical Association (AMA)
Jaffary, Fariba& Nilforoushzadeh, Mohammad Ali& Siadat, Amir Hossein& Haftbaradaran, Elaheh& Ansari, Nazli& Kheirkhah, Abbas. A Comparison between the Effects of Glucantime, Topical Trichloroacetic Acid 50% plus Glucantime, and Fractional Carbon Dioxide Laser plus Glucantime on Cutaneous Leishmaniasis Lesions. Dermatology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1103845
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103845