Protective Effect of Mangifera indica Linn., Cocos nucifera Linn., and Averrhoa carambola Linn. Extracts against Ultraviolet B-Induced Damage in Human Keratinocytes
Joint Authors
Tencomnao, Tewin
Pattarachotanant, Nattaporn
Ronpirin, Chalinee
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study was aimed at investigating the antioxidant activity of Mangifera indica Linn., Cocos nucifera Linn., and Averrhoa carambola Linn.
and their biological effect on human keratinocytes affected by the ultraviolet B (UVB), a major cause of cell damage and skin cancer through induction of DNA damage, production of reactive oxygen species (ROS), and apoptosis.
The richest antioxidant activity was found in ethanol fraction of M.
indica (21.32 ± 0.66 mg QE/g dry weight), while the lowest one was found in aqueous fractions of M.
indica and C.
nucifera (1.76 ± 2.10 and 1.65 ± 0.38 mg QE/g dry weight, respectively).
Ethanol and aqueous fractions of A.
carambola (250 µg/mL) significantly reduced the number of apoptotic cells.
The expression of cleaved caspase 3 in UVB-treated group was significantly greater than that in untreated group.
Both fractions of A.
carambola (50, 100, and 250 µg/mL) significantly decreased the expression of cleaved caspase 3.
Regarding the induction of DNA repair, ethanol (100 and 250 µg/mL) and aqueous (50, 100 and 250 µg/mL) fractions of A.
carambola significantly decreased the percentage of cyclobutane pyrimidine dimers (CPD).
Taken together, our results suggest that both fractions of A.
carambola may be potentially developed for dermal applications.
American Psychological Association (APA)
Ronpirin, Chalinee& Pattarachotanant, Nattaporn& Tencomnao, Tewin. 2016. Protective Effect of Mangifera indica Linn., Cocos nucifera Linn., and Averrhoa carambola Linn. Extracts against Ultraviolet B-Induced Damage in Human Keratinocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103921
Modern Language Association (MLA)
Ronpirin, Chalinee…[et al.]. Protective Effect of Mangifera indica Linn., Cocos nucifera Linn., and Averrhoa carambola Linn. Extracts against Ultraviolet B-Induced Damage in Human Keratinocytes. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103921
American Medical Association (AMA)
Ronpirin, Chalinee& Pattarachotanant, Nattaporn& Tencomnao, Tewin. Protective Effect of Mangifera indica Linn., Cocos nucifera Linn., and Averrhoa carambola Linn. Extracts against Ultraviolet B-Induced Damage in Human Keratinocytes. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103921