GC-MS Analysis: In Vivo Hepatoprotective and Antioxidant Activities of the Essential Oil of Achillea biebersteinii Afan. Growing in Saudi Arabia
Joint Authors
Mothana, R. A. A.
Al-Sohaibani, Mohammed
Khaled, Jamal M.
Alatar, Abdulrahman
Kurkcuoglu, Mine
Baser, Husnu C.
al-Said, Mansour
al-Harbi, Naif O.
al-Yahya, Mohammed
Rafatullah, Syed
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Liver disease is a worldwide problem.
It represents one of the main causes of morbidity and mortality in humans.
Achillea biebersteinii is used as herbal remedy for various ailments including liver diseases.
But the scientific basis for its medicinal use remains unknown.
Thus, this research was undertaken to evaluate the efficiency of A.
biebersteinii essential oil (ABEO) (0.2 mL/kg) in the amelioration of CCl4-induced hepatotoxicity in rodent model.
Moreover, the chemical content of the oil was investigated using GC and GC-MS.
The following biochemical parameters were evaluated: serum glutamic oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), gamma-glutamyl-transpeptidase (γ-GGT), alkaline phosphatase (ALP), and total bilirubin.
Furthermore, lipid profile, malondialdehyde (MDA), nonprotein sulfhydryl (NP-SH), and total protein (TP) contents in liver tissue were estimated.
44 components (92.0%) of the total oil have been identified by GC-MS analysis where α-terpinene and p -cymene were the most abundant.
The high serum enzymatic (GOT, GPT, GGT, and ALP) and bilirubin concentrations as well as the level of MDA, NP-SH, and TP contents in liver tissues were significantly reinstated towards normalization by the ABEO.
Histopathological study further confirmed these findings.
In addition, ABEO showed mild antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and β-carotene-linoleic acid assays.
American Psychological Association (APA)
al-Said, Mansour& Mothana, R. A. A.& al-Yahya, Mohammed& Rafatullah, Syed& Al-Sohaibani, Mohammed& Khaled, Jamal M.…[et al.]. 2016. GC-MS Analysis: In Vivo Hepatoprotective and Antioxidant Activities of the Essential Oil of Achillea biebersteinii Afan. Growing in Saudi Arabia. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103934
Modern Language Association (MLA)
al-Said, Mansour…[et al.]. GC-MS Analysis: In Vivo Hepatoprotective and Antioxidant Activities of the Essential Oil of Achillea biebersteinii Afan. Growing in Saudi Arabia. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103934
American Medical Association (AMA)
al-Said, Mansour& Mothana, R. A. A.& al-Yahya, Mohammed& Rafatullah, Syed& Al-Sohaibani, Mohammed& Khaled, Jamal M.…[et al.]. GC-MS Analysis: In Vivo Hepatoprotective and Antioxidant Activities of the Essential Oil of Achillea biebersteinii Afan. Growing in Saudi Arabia. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103934
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103934