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Comparison of the Effect of Velvet Antler from Different Sections on Longitudinal Bone Growth of Adolescent Rats
Joint Authors
Kim, Hye Kyung
Kim, Myung-Gyou
Leem, Kang-Hyun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this study was to compare the effectiveness of velvet antler (VA) from different sections for promoting longitudinal bone growth in growing rats.
VA was divided into upper (VAU), middle (VAM), and basal sections (VAB).
An in vivo study was performed to examine the effect on longitudinal bone growth in adolescent rats.
In addition, in vitro osteogenic activities were examined using osteoblastic MG-63 cells.
VA promoted longitudinal bone growth and height of the growth plate in adolescent rats.
Bone morphogenetic protein-2 (BMP-2) in growth plate of VA group was highly expressed compared with control.
The anabolic effect of VA on bone was further supported by in vitro study.
VA enhanced the proliferation, differentiation, and mineralization of MG-63 cells.
The mRNA expressions of osteogenic genes such as collagen, alkaline phosphatase, and osteocalcin were increased by VA treatment.
These effects of in vivo and in vitro study were decreased from upper to basal sections of VA.
In conclusion, VA treatment promotes longitudinal bone growth in growing rats through enhanced BMP-2 expression, osteogenic activities, and bone matrix gene expressions.
In addition, present study provides evidence for the regional differences in the effectiveness of velvet antler for longitudinal bone growth.
American Psychological Association (APA)
Kim, Hye Kyung& Kim, Myung-Gyou& Leem, Kang-Hyun. 2016. Comparison of the Effect of Velvet Antler from Different Sections on Longitudinal Bone Growth of Adolescent Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103940
Modern Language Association (MLA)
Kim, Hye Kyung…[et al.]. Comparison of the Effect of Velvet Antler from Different Sections on Longitudinal Bone Growth of Adolescent Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103940
American Medical Association (AMA)
Kim, Hye Kyung& Kim, Myung-Gyou& Leem, Kang-Hyun. Comparison of the Effect of Velvet Antler from Different Sections on Longitudinal Bone Growth of Adolescent Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103940
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103940