![](/images/graphics-bg.png)
Acupuncture Induces the Proliferation and Differentiation of Endogenous Neural Stem Cells in Rats with Traumatic Brain Injury
Joint Authors
Jiang, Shuting
Chen, Weihao
Zhang, Yimin
Zhang, Yujuan
Chen, Ailian
Dai, Qiufu
Lin, Shujun
Lin, Hanyu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To investigate whether acupuncture induced the proliferation and differentiation of endogenous neural stem cells (NSCs) in a rat model of traumatic brain injury (TBI).
Methods.
104 Sprague-Dawley rats were randomly divided into normal, model, and acupuncture groups.
Each group was subdivided into three-day (3 d), seven-day (7 d), and fourteen-day (14 d) groups.
The rat TBI model was established using Feeney’s freefall epidural impact method.
The rats in the acupuncture group were treated at acupoints (Baihui, Shuigou, Fengfu, Yamen, and bilateral Hegu).
The normal and model groups did not receive acupuncture.
The establishment of the rat TBI model and the therapeutic effect of acupuncture were assessed using neurobehavioral scoring and hematoxylin-eosin staining.
The proliferation and differentiation of NSCs in TBI rats were analyzed using immunofluorescence microscopy.
Results.
The levels of nestin-expressing cells and bromodeoxyuridine/glial fibrillary acidic protein- (BrdU/GFAP-) and BrdU/S100 calcium-binding protein B-positive and BrdU/microtubule-associated protein 2- and BrdU/galactocerebrosidase-positive cells were more significantly increased at various time points in the acupuncture group than in the model group (P<0.01), except for a decreased level of BrdU/GFAP-positive cells at 7 d and 14 d.
Conclusion.
Acupuncture induced the proliferation and differentiation of NSCs, thereby promoting neural repair in the TBI rats.
American Psychological Association (APA)
Jiang, Shuting& Chen, Weihao& Zhang, Yimin& Zhang, Yujuan& Chen, Ailian& Dai, Qiufu…[et al.]. 2016. Acupuncture Induces the Proliferation and Differentiation of Endogenous Neural Stem Cells in Rats with Traumatic Brain Injury. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103959
Modern Language Association (MLA)
Jiang, Shuting…[et al.]. Acupuncture Induces the Proliferation and Differentiation of Endogenous Neural Stem Cells in Rats with Traumatic Brain Injury. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103959
American Medical Association (AMA)
Jiang, Shuting& Chen, Weihao& Zhang, Yimin& Zhang, Yujuan& Chen, Ailian& Dai, Qiufu…[et al.]. Acupuncture Induces the Proliferation and Differentiation of Endogenous Neural Stem Cells in Rats with Traumatic Brain Injury. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1103959