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Pigmentation Effect of Rice Bran Extracted Minerals Comprising Soluble Silicic Acids
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Our investigation focused on identifying melanogenesis effect of soluble minerals in rice bran ash extract (RBE) which include orthosilicic acid (OSA).
Melanocytes were apparently normal in terms of morphology.
It was, however, shown that they were stressed a little in the RBE and OSA added media in aspect of LDH activity.
Melanin synthesis and intracellular tyrosinase activity were increased by treatment of RBE which is similar to that of OSA.
The Western blotting results showed that TRP-1, tyrosinase, and MITF expression levels were 2-3 times higher in the OSA and RBE groups compared to the control group which promoted melanin synthesis through CREB phosphorylation.
Moreover, histology and immunohistochemistry were shown to have similar result to that of protein expression.
As a result, minerals which comprise orthosilicic acid has the potential to promote melanogenesis and both RBE and OSA have similar cell viability, protein expression, and immunostaining results, suggesting that RBE comprises specific minerals which promote melanin synthesis through increasing of MITF and CREB phosphorylation.
Therefore, RBE could be used as a novel therapeutic approach to combat melanin deficiency related diseases by stimulating melanocytes via its soluble Si and mineral components.
American Psychological Association (APA)
Jang, Hyun-Jun& Seo, Young-Kwon. 2016. Pigmentation Effect of Rice Bran Extracted Minerals Comprising Soluble Silicic Acids. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104045
Modern Language Association (MLA)
Jang, Hyun-Jun& Seo, Young-Kwon. Pigmentation Effect of Rice Bran Extracted Minerals Comprising Soluble Silicic Acids. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104045
American Medical Association (AMA)
Jang, Hyun-Jun& Seo, Young-Kwon. Pigmentation Effect of Rice Bran Extracted Minerals Comprising Soluble Silicic Acids. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104045
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104045