Attenuation of Oxidative Stress of Erythrocytes by Plant-Derived Flavonoids, Orientin and Luteolin
Joint Authors
Gong, Yuewen
An, Fang
Wang, Shulin
Yuan, Danhua
Wang, Shuhua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Erythrocytes are easy to be injured by oxidative stress in their lifespan.
Although there are several chemicals such as vitamin C (VC) that would be able to reduce oxidative stress, natural herbal products still remain an interesting research area.
The current study investigated the effects of two plant-derived flavonoids, orientin and luteolin, on erythrocytes and their possible mechanisms.
This experiment was divided into nine groups, which were normal group, model group, VC control group, and treated groups with different doses of orientin and luteolin (10, 20, and 40 μg/mL), respectively.
Hemolysis rate was determined by spectrophotometry.
Antioxidative enzyme and products were evaluated by different methods.
Erythrocyte cell surface and cellular structure were observed with scanning or transmission electron microscope, respectively.
Oxidative stress induced significant increase in hemolysis rate of erythrocytes.
Orientin or luteolin ameliorated hemolysis of erythrocytes in oxidative stress in a dose-dependent manner.
Both orientin and luteolin reduced oxidative products and increased antioxidative enzyme activities.
Moreover, orientin and luteolin attenuated oxidative stress induced damage of erythrocyte cell surface morphology and cellular structure.
In conclusion, orientin and luteolin could protect human erythrocytes from oxidative damage by attenuating oxidative stress, protecting antioxidative enzyme activities, and preserving integrity of erythrocyte structure.
American Psychological Association (APA)
An, Fang& Wang, Shulin& Yuan, Danhua& Gong, Yuewen& Wang, Shuhua. 2016. Attenuation of Oxidative Stress of Erythrocytes by Plant-Derived Flavonoids, Orientin and Luteolin. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104066
Modern Language Association (MLA)
An, Fang…[et al.]. Attenuation of Oxidative Stress of Erythrocytes by Plant-Derived Flavonoids, Orientin and Luteolin. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104066
American Medical Association (AMA)
An, Fang& Wang, Shulin& Yuan, Danhua& Gong, Yuewen& Wang, Shuhua. Attenuation of Oxidative Stress of Erythrocytes by Plant-Derived Flavonoids, Orientin and Luteolin. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104066
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104066