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Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells: Rubus suavissimus Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells
Joint Authors
Takahashi, Tomohiro
Sugawara, Wataru
Takiguchi, Yuya
Takizawa, Kento
Nakabayashi, Ami
Nakamura, Mitsuo
Nagano-Ito, Michiyo
Ichikawa, Shinichi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Fatty liver disease is a condition in which abnormally large numbers of lipid droplets accumulate in liver cells.
Fatty liver disease induces inflammation under conditions of oxidative stress and may result in cancer.
To identify plants that protect against fatty liver disease, we examined the inhibitory effects of plant extracts on lipid droplet formation in mouse hepatoma cells.
A screen of 98 water extracts of plants revealed 4 extracts with inhibitory effects.
One of these extracts, Rubus suavissimus S.
Lee (Tien-cha or Chinese sweet tea) leaf extract, which showed strong inhibitory effects, was tested in a mouse fatty liver model.
In these mouse experiments, intake of the plant extract significantly protected mice against fatty liver disease without affecting body weight gain.
Our results suggest that RSE directly affects liver cells and protects them from fatty liver disease.
American Psychological Association (APA)
Takahashi, Tomohiro& Sugawara, Wataru& Takiguchi, Yuya& Takizawa, Kento& Nakabayashi, Ami& Nakamura, Mitsuo…[et al.]. 2016. Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells: Rubus suavissimus Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104136
Modern Language Association (MLA)
Takahashi, Tomohiro…[et al.]. Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells: Rubus suavissimus Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104136
American Medical Association (AMA)
Takahashi, Tomohiro& Sugawara, Wataru& Takiguchi, Yuya& Takizawa, Kento& Nakabayashi, Ami& Nakamura, Mitsuo…[et al.]. Identification of Plants That Inhibit Lipid Droplet Formation in Liver Cells: Rubus suavissimus Leaf Extract Protects Mice from High-Fat Diet-Induced Fatty Liver by Directly Affecting Liver Cells. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104136
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104136