Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites
Joint Authors
Chen, Xiaojia
Wan, Jian-Bo
Zhang, Xiao-Jing
Shui, Yan-Mei
Gao, Jian-Li
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Recently, most anticancer drugs are derived from natural resources such as marine, microbial, and botanical sources, but the low success rates of chemotherapies and the development of multidrug resistance emphasize the importance of discovering new compounds that are both safe and effective against cancer.
Ginseng types, including Asian ginseng, American ginseng, and notoginseng, have been used traditionally to treat various diseases, due to their immunomodulatory, neuroprotective, antioxidative, and antitumor activities.
Accumulating reports have shown that ginsenosides, the major active component of ginseng, were helpful for tumor treatment.
20(S)-Protopanaxadiol (PDS) and 20(S)-protopanaxatriol saponins (PTS) are two characteristic types of triterpenoid saponins in ginsenosides.
PTS holds capacity to interfere with crucial metabolism, while PDS could affect cell cycle distribution and prodeath signaling.
This review aims at providing an overview of PTS and PDS, as well as their metabolites, regarding their different anticancer effects with the proposal that these compounds might be potent additions to the current chemotherapeutic strategy against cancer.
American Psychological Association (APA)
Chen, Xiaojia& Zhang, Xiao-Jing& Shui, Yan-Mei& Wan, Jian-Bo& Gao, Jian-Li. 2016. Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1104225
Modern Language Association (MLA)
Chen, Xiaojia…[et al.]. Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1104225
American Medical Association (AMA)
Chen, Xiaojia& Zhang, Xiao-Jing& Shui, Yan-Mei& Wan, Jian-Bo& Gao, Jian-Li. Anticancer Activities of Protopanaxadiol- and Protopanaxatriol-Type Ginsenosides and Their Metabolites. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1104225
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104225