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Inhibition of Asthma in OVA Sensitized Mice Model by a Traditional Uygur Herb Nepeta bracteata Benth.
Joint Authors
Ding, Jianbing
Pang, Nannan
Wang, Jing
Li, Feng-sen
Tian, Ge
Jiang, Min
Zhang, Hong-ping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Asthma is a chronic lung inflammation which affects many people.
As current therapies for asthma mainly rely on administration of glucocorticoids and have many side effects, new therapy is needed.
In this study, we investigated Nepeta bracteata Benth., a traditional Uygur Herb, for its therapeutics effect in OVA induced asthmatic mice model.
Treatment of OVA sensitized asthma mice with extract from Nepeta bracteata Benth.
demonstrated improved lung pathology, as well as reduced infiltration of eosinophil and neutrophil.
Nepeta bracteata Benth.
extract also contributed to the rebalance of Th17/Treg cell via decreasing the Th17 cell and increasing the Treg, which was corresponding with the inhibited Th17 cytokine response and increased IL-10 level.
Moreover, the reduced TGF-β level and Smad2/3 protein level also suggested that Nepeta bracteata Benth.
extract could inhibit TGF-β mediated airway remodelling as well.
Taken together, these data suggested that Nepeta bracteata Benth.
may be a novel candidate for future antiasthma drug development.
American Psychological Association (APA)
Wang, Jing& Li, Feng-sen& Pang, Nannan& Tian, Ge& Jiang, Min& Zhang, Hong-ping…[et al.]. 2016. Inhibition of Asthma in OVA Sensitized Mice Model by a Traditional Uygur Herb Nepeta bracteata Benth.. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104228
Modern Language Association (MLA)
Wang, Jing…[et al.]. Inhibition of Asthma in OVA Sensitized Mice Model by a Traditional Uygur Herb Nepeta bracteata Benth.. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104228
American Medical Association (AMA)
Wang, Jing& Li, Feng-sen& Pang, Nannan& Tian, Ge& Jiang, Min& Zhang, Hong-ping…[et al.]. Inhibition of Asthma in OVA Sensitized Mice Model by a Traditional Uygur Herb Nepeta bracteata Benth.. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104228