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Exploratory, Phase II Controlled Trial of Shiunko Ointment Local Application Twice a Day for 4 Weeks in Ethiopian Patients with Localized Cutaneous Leishmaniasis
Joint Authors
Na-Bangchang, Kesara
Ahmed, Oumer
Hussein, Jemal
Hirayama, Kenji
Kongjam, Panida
Karbwang, Juntra
Aseffa, Abraham
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The clinical efficacy and safety of Shiunko ointment (phase II clinical trial) was investigated in 40 Ethiopian patients with cutaneous leishmaniasis.
Patients were randomized to receive treatment with Shiunko ointment or placebo ( n = 20 , each), applied on the lesion twice a day for 4 weeks.
Clinicoparasitological assessments were performed before treatment, weekly for 4 weeks, and then 4, 8, and 12 weeks after the end of treatment.
A marked reduction in lesion size was observed on week 16 of treatment in the Shiunko compared with placebo group (69% and 22% reduction, resp.).
The overall rate of lesion reduction during the four weeks of treatment was significantly faster in the Shiunko group.
Shiunko provided significant effect on wound closure in patients with ulcerated lesion.
The clinical efficacy and tolerability of Shiunko were comparable to placebo with regard to its clinicoparasitological response (cure rate and parasitological clearance).
Results of this preliminary study may suggest that Shiunko could be useful as adjuvant or as complementary treatment, not as alternatives to current treatment.
Its attractive action includes fast lesion healing with a significantly smaller lesion at week 16 of treatment compared with placebo.
In addition, its action was promoted in ulcerative lesions.
American Psychological Association (APA)
Na-Bangchang, Kesara& Ahmed, Oumer& Hussein, Jemal& Hirayama, Kenji& Kongjam, Panida& Aseffa, Abraham…[et al.]. 2016. Exploratory, Phase II Controlled Trial of Shiunko Ointment Local Application Twice a Day for 4 Weeks in Ethiopian Patients with Localized Cutaneous Leishmaniasis. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104251
Modern Language Association (MLA)
Na-Bangchang, Kesara…[et al.]. Exploratory, Phase II Controlled Trial of Shiunko Ointment Local Application Twice a Day for 4 Weeks in Ethiopian Patients with Localized Cutaneous Leishmaniasis. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104251
American Medical Association (AMA)
Na-Bangchang, Kesara& Ahmed, Oumer& Hussein, Jemal& Hirayama, Kenji& Kongjam, Panida& Aseffa, Abraham…[et al.]. Exploratory, Phase II Controlled Trial of Shiunko Ointment Local Application Twice a Day for 4 Weeks in Ethiopian Patients with Localized Cutaneous Leishmaniasis. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104251