Antibacterial Activity of Salvadora persica L. (Miswak) Extracts against Multidrug Resistant Bacterial Clinical Isolates
Joint Authors
Al-Ayed, Mohamed Saeed Zayed
Asaad, Ahmed Morad
Qureshi, Mohamed Ansar
Attia, Hany Goda
AlMarrani, Abduljabbar Hadi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Much effort has focused on examining the inhibitory effect of Salvadora persica (miswak) on oral microorganisms, but information concerning its antibacterial activity against other human pathogens, particularly multidrug resistant (MDR) isolates, is scarce.
Therefore, this study aimed to assess the in vitro antibacterial activities of Salvadora persica L.
extracts against 10 MDR bacterial clinical isolates other than oral pathogens.
The antibacterial activity of aqueous and methanol miswak extracts was assessed using the agar dilution and minimum inhibitory concentration (MIC) methods.
Overall, the 400 mg/mL of miswak extract was the most effective on all strains.
The methanol extract exhibited a stronger antibacterial activity against Gram-negative (3.3–13.6 mm) than Gram-positive (1.8–8.3 mm) bacteria.
The lowest MIC value was seen for E.
coli (0.39, 1.56 µg/mL), followed by Streptococcus pyogenes (1.56 µg/mL).
The highest MIC value (6.25, 12.5 µg/mL) was recorded for methicillin-resistant Staphylococcus aureus (MRSA), Acinetobacter baumannii, and Stenotrophomonas maltophilia.
This study demonstrates, for the first time, the moderate to strong antibacterial activity of miswak extracts against all tested MDR-pathogens.
Methanol extract appears to be a potent antimicrobial agent that could be considered as complementary and alternative medicine against resistant pathogens.
Further studies on a large number of MDR organisms are necessary to investigate and standardize the inhibitory effect of miswak extracts against these emerging pathogens.
American Psychological Association (APA)
Al-Ayed, Mohamed Saeed Zayed& Asaad, Ahmed Morad& Qureshi, Mohamed Ansar& Attia, Hany Goda& AlMarrani, Abduljabbar Hadi. 2016. Antibacterial Activity of Salvadora persica L. (Miswak) Extracts against Multidrug Resistant Bacterial Clinical Isolates. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104320
Modern Language Association (MLA)
Al-Ayed, Mohamed Saeed Zayed…[et al.]. Antibacterial Activity of Salvadora persica L. (Miswak) Extracts against Multidrug Resistant Bacterial Clinical Isolates. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1104320
American Medical Association (AMA)
Al-Ayed, Mohamed Saeed Zayed& Asaad, Ahmed Morad& Qureshi, Mohamed Ansar& Attia, Hany Goda& AlMarrani, Abduljabbar Hadi. Antibacterial Activity of Salvadora persica L. (Miswak) Extracts against Multidrug Resistant Bacterial Clinical Isolates. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104320
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104320