Clinical Presentation, Risk Factors, and Treatment Modalities of Hepatocellular Carcinoma: A Single Tertiary Care Center Experience
Joint Authors
Kuriry, H.
Aljumah, Abdulrahman A.
AlZunaitan, Mohammed
Al Ghobain, Mohammed
Al Muaikeel, Mohamed
Al Olayan, Ashwaq
Azzumeea, Fahad
AlAlwan, Abduljaleel
AlGhamdi, Hamdan
Almutairi, Bader
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To investigate the risk factors, clinical characteristics, treatment modalities, and outcomes in Saudi patients with HCC and propose points for early detection of the disease.
Methods.
Patients were stratified according to underlying risk factors for the development of HCC.
Barcelona Clinic Liver Cancer (BCLC) was used for cancer staging.
Treatment was classified into surgical resection/liver transplantation; locoregional ablation therapy; transarterial embolization; systemic chemotherapy; and best supportive care.
Results.
A total of 235 patients were included.
Males had higher tumor size and incidence of portal vein thrombosis.
Viral hepatitis was a risk factor in 75.7%.
The most common BCLC stages were B (34.5%) and A (33.6%), and the most common radiological presentation was a single nodule of less than 5 cm.
Metastases were present in 13.2%.
Overall, 77 patients (32.8%) underwent a potentially curative treatment as the initial therapy.
The most commonly utilized treatment modality was chemoembolization with 113 sessions in 71 patients.
The overall median survival was 15.97 ± 27.18 months.
Conclusion.
HCC in Saudi Arabia is associated with high prevalence of HCV.
Potentially curative therapies were underutilized in our patients.
Cancer stage BCLC-B was the most frequent (34.5%) followed by BCLC-A (33.6%).
The overall median survival was shorter than other studies.
American Psychological Association (APA)
Aljumah, Abdulrahman A.& Kuriry, H.& AlZunaitan, Mohammed& Al Ghobain, Mohammed& Al Muaikeel, Mohamed& Al Olayan, Ashwaq…[et al.]. 2016. Clinical Presentation, Risk Factors, and Treatment Modalities of Hepatocellular Carcinoma: A Single Tertiary Care Center Experience. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104605
Modern Language Association (MLA)
Aljumah, Abdulrahman A.…[et al.]. Clinical Presentation, Risk Factors, and Treatment Modalities of Hepatocellular Carcinoma: A Single Tertiary Care Center Experience. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1104605
American Medical Association (AMA)
Aljumah, Abdulrahman A.& Kuriry, H.& AlZunaitan, Mohammed& Al Ghobain, Mohammed& Al Muaikeel, Mohamed& Al Olayan, Ashwaq…[et al.]. Clinical Presentation, Risk Factors, and Treatment Modalities of Hepatocellular Carcinoma: A Single Tertiary Care Center Experience. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104605
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104605