Do NSAIDs and ASA Cause More Upper Gastrointestinal Bleeding in Elderly than Adults?
Joint Authors
Okuturlar, Yıldız
Harmankaya, Özlem
Kocoglu, Hakan
Oguz, Basak
Dogan, Hakan
Hursitoglu, Mehmet
Altuntas, Yuksel
Kumbasar, Abdulbaki
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
NSAIDs and ASA may cause upper gastrointestinal bleeding (UGIB) both in adults and in elderly.
There is no study that compares this increased bleeding risk between adult and elderly subjects.
Methods.
A total of 524 patients with UGIB were included in this study.
The data of patients were, respectively, analyzed.
Results.
NSAIDs and ASA-associated UGIB rates were similar between <65 years (345 patients) (group 1) and ≥65 years (179 patients) (group 2) (28.4% versus 23.5%, p=0.225 and 13% versus 19%, p=0.071, resp.).
Warfarin-associated UGIB was found significantly higher in group 2 than group 1.
Elderly patients with NSAID-associated UGIB had significantly higher length of stay (LoS) and CoH than adult patients with NSAID-associated UGIB (p=0.002 and 0.001, resp.).
Elderly patients with ASA-associated UGIB had significantly higher CoH than adult patients with NSAID-associated UGIB.
Conclusions.
Using NSAIDs without gastroprotective drugs or using ASA with gastroprotective drugs in elderly patients is as safe as in adult patients.
Not only should adding gastroprotective drugs to ASA or NSAID be based on their risk of UGIB, but the cost of hospitalization of ASA or NSAID-associated UGIB should be considered.
American Psychological Association (APA)
Kocoglu, Hakan& Oguz, Basak& Dogan, Hakan& Okuturlar, Yıldız& Hursitoglu, Mehmet& Harmankaya, Özlem…[et al.]. 2016. Do NSAIDs and ASA Cause More Upper Gastrointestinal Bleeding in Elderly than Adults?. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104808
Modern Language Association (MLA)
Kocoglu, Hakan…[et al.]. Do NSAIDs and ASA Cause More Upper Gastrointestinal Bleeding in Elderly than Adults?. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1104808
American Medical Association (AMA)
Kocoglu, Hakan& Oguz, Basak& Dogan, Hakan& Okuturlar, Yıldız& Hursitoglu, Mehmet& Harmankaya, Özlem…[et al.]. Do NSAIDs and ASA Cause More Upper Gastrointestinal Bleeding in Elderly than Adults?. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104808
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104808