Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, China
Joint Authors
Lan, Chun-Hui
Han, Ran
Hu, Jiali
Lu, Hong
Jiang, Ming-Wan
Tan, Ke-Wen
Peng, Zhong
Fang, Dian-Chun
Wu, Xiao-Ling
Source
Gastroenterology Research and Practice
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study was to investigate the antibiotic resistance profile of H.
pylori and the distribution of CYP2C19 gene polymorphism in rural population of Chongqing, China.
214 and 111 strains of H.
pylori were isolated from rural and urban patients, respectively.
99.53%, 20.09%, and 23.36% of the isolates in rural patients were found to be resistant to metronidazole, clarithromycin, and levofloxacin, while the resistant rate in urban patients was 82.88%, 19.82%, and 24.32%.
The multiple antibiotic resistance percentage significantly increased from 28.26% (below 45 years) to 41.80% (above 45 years) in rural patients.
Up to 44.39%, 45.79%, and 9.81% of rural patients from whom H.
pylori was isolated were found to be extensive metabolizers, intermediate metabolizers, and poor metabolizers.
No correlation was observed between antibiotic resistance profile of H.
pylori and genetic polymorphism of CYP2C19 among rural population.
There was a high prevalence of H.
pylori strains resistant to metronidazole, clarithromycin, and levofloxacin in rural patients in Chongqing, China.
The choice of therapy in this area should be based on local susceptibility patterns.
Amoxicillin, gentamicin, and furazolidone are recommended as the first-line empiric regimen.
American Psychological Association (APA)
Han, Ran& Lu, Hong& Jiang, Ming-Wan& Tan, Ke-Wen& Peng, Zhong& Hu, Jiali…[et al.]. 2016. Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, China. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104815
Modern Language Association (MLA)
Han, Ran…[et al.]. Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, China. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1104815
American Medical Association (AMA)
Han, Ran& Lu, Hong& Jiang, Ming-Wan& Tan, Ke-Wen& Peng, Zhong& Hu, Jiali…[et al.]. Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution of CYP2C19 Gene Polymorphism in Rural Population of Chongqing, China. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104815
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1104815