Evaluation of Subclinical Hypothyroidism in Children and Adolescents: A Single-Center Study
Joint Authors
Malecka-Tendera, Ewa
Gawlik, Aneta
Such, Kamila
Dejner, Aleksandra
Zachurzok, Agnieszka
Antosz, Aleksandra
Gawlik, Tomasz
Wasniewska, Malgorzata
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The main purpose of our retrospective study was to evaluate the medical care of the patients with subclinical hypothyroidism (sHT) and to investigate the rationale for administering L-thyroxine (LT-4) to young sHT patients.
Patients and Methods.
Based on a retrospective review of the charts of 261 patients referred to the Endocrinology Outpatient Clinic between 2009 and 2014 with suspicion of sHT, 55 patients were enrolled for further analysis.
Data collected was baseline age, anthropometric measurements, serum TSH, fT4, fT3, anti-thyroid autoantibodies, positive family history, absence/presence of clinical symptoms, length of follow-up, and data concerning LT-4 therapy (therapy: T1; no therapy: T0).
Results.
T1 encompassed 33 (60.0%) patients.
There were no differences between T1 and T0 ( p > 0.05 ) with regard to age, TSH concentrations, BMI Z -score, and hSDS values, though follow-up was longer in T1 ( p < 0.01 ).
Four (11.8%) children in T1 and none in T0 had a positive family history of thyroid disorders.
Fifteen (68.2%) patients in group T0 became euthyroid.
One (1.8%) girl (T1) developed overt hypothyroidism.
Conclusions.
A small percentage of patients can proceed to overt hypothyroidism.
Only positive family history seemed to influence the decision to initiate LT-4 therapy.
Further prospective studies are warranted in order to establish treatment indications, if any, and the mean recommended dosage of LT-4.
American Psychological Association (APA)
Such, Kamila& Gawlik, Aneta& Dejner, Aleksandra& Wasniewska, Malgorzata& Zachurzok, Agnieszka& Antosz, Aleksandra…[et al.]. 2016. Evaluation of Subclinical Hypothyroidism in Children and Adolescents: A Single-Center Study. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105765
Modern Language Association (MLA)
Such, Kamila…[et al.]. Evaluation of Subclinical Hypothyroidism in Children and Adolescents: A Single-Center Study. International Journal of Endocrinology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1105765
American Medical Association (AMA)
Such, Kamila& Gawlik, Aneta& Dejner, Aleksandra& Wasniewska, Malgorzata& Zachurzok, Agnieszka& Antosz, Aleksandra…[et al.]. Evaluation of Subclinical Hypothyroidism in Children and Adolescents: A Single-Center Study. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105765