![](/images/graphics-bg.png)
Evidences of Polymorphism Associated with Circadian System and Risk of Pathologies: A Review of the Literature
Joint Authors
Vera, J.
Venegas, C.
Lagunas, C.
Muñoz, S.
Oyarce, S.
Muñoz, K.
Valenzuela, Francisco J.
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The circadian system is a supraphysiological system that modulates different biological functions such as metabolism, sleep-wake, cellular proliferation, and body temperature.
Different chronodisruptors have been identified, such as shift work, feeding time, long days, and stress.
The environmental changes and our modern lifestyle can alter the circadian system and increase the risk of developing pathologies such as cancer, preeclampsia, diabetes, and mood disorder.
This system is organized by transcriptional/tranductional feedback loops of clock genes Clock, Bmal1, Per1–3, and Cry1-2.
How molecular components of the clock are able to influence the development of diseases and their risk relation with genetic components of polymorphism of clock genes is unknown.
This research describes different genetic variations in the population and how these are associated with risk of cancer, metabolic diseases such as diabetes, obesity, and dyslipidemias, and also mood disorders such as depression, bipolar disease, excessive alcohol intake, and infertility.
Finally, these findings will need to be implemented and evaluated at the level of genetic interaction and how the environment factors trigger the expression of these pathologies will be examined.
American Psychological Association (APA)
Valenzuela, Francisco J.& Vera, J.& Venegas, C.& Muñoz, S.& Oyarce, S.& Muñoz, K.…[et al.]. 2016. Evidences of Polymorphism Associated with Circadian System and Risk of Pathologies: A Review of the Literature. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1105830
Modern Language Association (MLA)
Valenzuela, Francisco J.…[et al.]. Evidences of Polymorphism Associated with Circadian System and Risk of Pathologies: A Review of the Literature. International Journal of Endocrinology No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1105830
American Medical Association (AMA)
Valenzuela, Francisco J.& Vera, J.& Venegas, C.& Muñoz, S.& Oyarce, S.& Muñoz, K.…[et al.]. Evidences of Polymorphism Associated with Circadian System and Risk of Pathologies: A Review of the Literature. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1105830
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105830